Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China
Abstract Background The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance. Methods In 2023, a vaccine-derived poliovirus (VDPV) strain ty...
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BMC
2025-06-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-025-02827-2 |
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| author | Wei Zhang Dongmei Yan Hanri Zeng Lei Zhou Huanying Zheng Shuangli Zhu Yong Zhang Baisheng Li |
| author_facet | Wei Zhang Dongmei Yan Hanri Zeng Lei Zhou Huanying Zheng Shuangli Zhu Yong Zhang Baisheng Li |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Abstract Background The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance. Methods In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed. Result The strain had reversion mutations at the known attenuation site 5’ non-coding region and recombined with Sabin1, Phylogenetic analysis of the VP1 coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally. Conclusion It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses. |
| format | Article |
| id | doaj-art-d576f8bb799d464b985c7c8ea600043b |
| institution | OA Journals |
| issn | 1743-422X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-d576f8bb799d464b985c7c8ea600043b2025-08-20T02:37:57ZengBMCVirology Journal1743-422X2025-06-012211810.1186/s12985-025-02827-2Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in ChinaWei Zhang0Dongmei Yan1Hanri Zeng2Lei Zhou3Huanying Zheng4Shuangli Zhu5Yong Zhang6Baisheng Li7Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical SciencesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionGuangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical SciencesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionGuangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical SciencesNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionGuangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Chinese Academy of Medical SciencesAbstract Background The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance. Methods In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed. Result The strain had reversion mutations at the known attenuation site 5’ non-coding region and recombined with Sabin1, Phylogenetic analysis of the VP1 coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally. Conclusion It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.https://doi.org/10.1186/s12985-025-02827-2PoliovirusHand, foot, and mouth diseaseVaccine-derived poliovirus |
| spellingShingle | Wei Zhang Dongmei Yan Hanri Zeng Lei Zhou Huanying Zheng Shuangli Zhu Yong Zhang Baisheng Li Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China Virology Journal Poliovirus Hand, foot, and mouth disease Vaccine-derived poliovirus |
| title | Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China |
| title_full | Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China |
| title_fullStr | Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China |
| title_full_unstemmed | Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China |
| title_short | Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China |
| title_sort | genetic characterization of type 3 vaccine derived poliovirus from a patient with hand foot and mouth disease in china |
| topic | Poliovirus Hand, foot, and mouth disease Vaccine-derived poliovirus |
| url | https://doi.org/10.1186/s12985-025-02827-2 |
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