Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia
Aim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative c...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/214581 |
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| author | Yaşar Doğan Tülay Erkan Zerrin Önal Merve Usta Gülen Doğusoy Fügen Çullu Çokuğraş Tufan Kutlu |
| author_facet | Yaşar Doğan Tülay Erkan Zerrin Önal Merve Usta Gülen Doğusoy Fügen Çullu Çokuğraş Tufan Kutlu |
| author_sort | Yaşar Doğan |
| collection | DOAJ |
| description | Aim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.
Results. The study included 64 cases (average: 10.2±0.4
years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5±4.7% and 1.9±0.1, respectively. Hp-negative cases showed significantly different values of 17.8±4.5% and 1.3±0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7±0.2g/dL and 32.5±2ng/mL, but these were comparable with Hp-negative cases (12.6±0.1g/dL and 30.7±4.4ng/mL). Conclusions. Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients. |
| format | Article |
| id | doaj-art-d574195d8d3a4c3e9e32e261c4f19ea8 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d574195d8d3a4c3e9e32e261c4f19ea82025-08-20T03:19:47ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/214581214581Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on AnemiaYaşar Doğan0Tülay Erkan1Zerrin Önal2Merve Usta3Gülen Doğusoy4Fügen Çullu Çokuğraş5Tufan Kutlu6Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDepartment of Medical Pathology, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Cerrahpaşa Medical Faculty, İstanbul University, İstanbul 23119, TurkeyAim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups. Results. The study included 64 cases (average: 10.2±0.4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5±4.7% and 1.9±0.1, respectively. Hp-negative cases showed significantly different values of 17.8±4.5% and 1.3±0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7±0.2g/dL and 32.5±2ng/mL, but these were comparable with Hp-negative cases (12.6±0.1g/dL and 30.7±4.4ng/mL). Conclusions. Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.http://dx.doi.org/10.1155/2012/214581 |
| spellingShingle | Yaşar Doğan Tülay Erkan Zerrin Önal Merve Usta Gülen Doğusoy Fügen Çullu Çokuğraş Tufan Kutlu Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia Mediators of Inflammation |
| title | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia |
| title_full | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia |
| title_fullStr | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia |
| title_full_unstemmed | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia |
| title_short | Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia |
| title_sort | lactoferrin levels in the gastric tissue of helicobacter pylori positive and negative patients and its effect on anemia |
| url | http://dx.doi.org/10.1155/2012/214581 |
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