Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults

Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults

BackgroundSignificant phenotypic and functional differences in peripheral lymphocyte subsets between infants and the elderly contribute to age-related variations in disease susceptibility and clinical outcomes. However, we are unable to specifically analyze the underlying causes owing to a lack of d...

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Bibliographic Details
Main Authors: Ting Ge, Guixin He, Qian Cui, Shuangcui Wang, Zekun Wang, Yingying Xie, Yuanyuan Tian, Juyue Zhou, Wentao Li, Baohui Wang, Keming Zhang, Jianchun Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
peripheral blood lymphocyte subsets
absolute counts
CD4 +/CD8 + ratio
infants
older adults
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1599515/full
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