Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers
This experiment was performed to investigate the impacts of formic acid polymer (FAP) supplementation to the diet on the growth performance, blood metabolites, as well as intestinal barrier function related indicators of broilers under lipopolysaccharide (LPS) stimulation. A total of 450 1-day-old m...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587832/full |
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| author | Guohui Zhou Yilin Ge Yuemeng Fu Changfei An Changjin Li Yang Li Weiren Yang Ning Jiao Jiali Chen |
| author_facet | Guohui Zhou Yilin Ge Yuemeng Fu Changfei An Changjin Li Yang Li Weiren Yang Ning Jiao Jiali Chen |
| author_sort | Guohui Zhou |
| collection | DOAJ |
| description | This experiment was performed to investigate the impacts of formic acid polymer (FAP) supplementation to the diet on the growth performance, blood metabolites, as well as intestinal barrier function related indicators of broilers under lipopolysaccharide (LPS) stimulation. A total of 450 1-day-old male Arbor Acres broilers with similar body weights were assigned to one of three experimental groups: control (CON) group, basal diet; LPS group, basal diet with LPS (1 mg/kg body weight) challenge; LPS+FAP group, basal diet supplemented with FAP (1,000 mg/kg) and LPS (1 mg/kg body weight) challenge. Each group had 6 replicates of 25 broilers. LPS was injected on days 17, 19, and 21. Samples were collected on day 21, 3 h post-challenge. The experiment lasted 21 days. LPS treatment reduced growth performance, immune function, and caused systemic inflammation, intestinal barrier damage, and microbiota dysbiosis in broilers. However, FAP supplementation significantly reversed these effects by reducing the feed-to-gain ratio and serum levels of interleukin (IL)-1β and tumor necrosis factor-α (P < 0.05), while increasing serum levels of complement C4, IL-10, and immunoglobulin M (P < 0.05). FAP also improved villus height, trefoil factor family, and mucin 2 levels, decreased caspase activities (P < 0.05), and reduced harmful bacteria while promoting beneficial bacteria. To sum up, supplementing 1,000 mg/kg of FAP to the diet effectively enhanced immune function, and mitigated the systemic inflammatory response and intestinal barrier damage caused by LPS, thereby improving broiler growth performance. |
| format | Article |
| id | doaj-art-d56e52b827be481cb2fa2e98060eddee |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-d56e52b827be481cb2fa2e98060eddee2025-08-20T02:33:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15878321587832Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilersGuohui Zhou0Yilin Ge1Yuemeng Fu2Changfei An3Changjin Li4Yang Li5Weiren Yang6Ning Jiao7Jiali Chen8Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaSDU-ANU Joint Science College, Shandong University, Wenhuaxilu, Weihai, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaBureau of Agriculture and Rural Affairs, Jiangbei Watertown Resort District, Liaocheng, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, ChinaThis experiment was performed to investigate the impacts of formic acid polymer (FAP) supplementation to the diet on the growth performance, blood metabolites, as well as intestinal barrier function related indicators of broilers under lipopolysaccharide (LPS) stimulation. A total of 450 1-day-old male Arbor Acres broilers with similar body weights were assigned to one of three experimental groups: control (CON) group, basal diet; LPS group, basal diet with LPS (1 mg/kg body weight) challenge; LPS+FAP group, basal diet supplemented with FAP (1,000 mg/kg) and LPS (1 mg/kg body weight) challenge. Each group had 6 replicates of 25 broilers. LPS was injected on days 17, 19, and 21. Samples were collected on day 21, 3 h post-challenge. The experiment lasted 21 days. LPS treatment reduced growth performance, immune function, and caused systemic inflammation, intestinal barrier damage, and microbiota dysbiosis in broilers. However, FAP supplementation significantly reversed these effects by reducing the feed-to-gain ratio and serum levels of interleukin (IL)-1β and tumor necrosis factor-α (P < 0.05), while increasing serum levels of complement C4, IL-10, and immunoglobulin M (P < 0.05). FAP also improved villus height, trefoil factor family, and mucin 2 levels, decreased caspase activities (P < 0.05), and reduced harmful bacteria while promoting beneficial bacteria. To sum up, supplementing 1,000 mg/kg of FAP to the diet effectively enhanced immune function, and mitigated the systemic inflammatory response and intestinal barrier damage caused by LPS, thereby improving broiler growth performance.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587832/fullbroilerformic acidgut microbiotainflammationintestinal barrier |
| spellingShingle | Guohui Zhou Yilin Ge Yuemeng Fu Changfei An Changjin Li Yang Li Weiren Yang Ning Jiao Jiali Chen Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers Frontiers in Microbiology broiler formic acid gut microbiota inflammation intestinal barrier |
| title | Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers |
| title_full | Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers |
| title_fullStr | Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers |
| title_full_unstemmed | Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers |
| title_short | Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers |
| title_sort | effects of dietary formic acid polymer supplementation on growth performance blood parameters and intestinal health in lipopolysaccharide challenged broilers |
| topic | broiler formic acid gut microbiota inflammation intestinal barrier |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587832/full |
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