Brain Injury and Ketamine study (BIKe): a prospective, randomized controlled double blind clinical trial to study the effects of ketamine on therapy intensity level and intracranial pressure in severe traumatic brain injury patients

Brain Injury and Ketamine study (BIKe): a prospective, randomized controlled double blind clinical trial to study the effects of ketamine on therapy intensity level and intracranial pressure in severe traumatic brain injury patients

Abstract Background In severe traumatic brain injury (TBI), sedatives are often used to control intracranial pressure (ICP), to reduce brain metabolism, to allow for other treatments such as mechanical ventilation or targeted temperature management, or to control paroxysmal sympathetic hyperactivity...

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Main Authors: Veerle De Sloovere, Liese Mebis, Pieter Wouters, Fabian Guïza, Eva Boonen, Marc Bourgeois, Jasperina Dubois, Didier Ledoux, Piet Lormans, Hugues Maréchal, Emmanuel Van der Hauwaert, Bart Depreitere, Geert Meyfroidt
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Trials
Subjects:
Brain injury
Traumatic wounds
Ketamine
Cranio-cerebral trauma
Central nervous system
Analgesics
Online Access:https://doi.org/10.1186/s13063-025-08835-5
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https://doi.org/10.1186/s13063-025-08835-5

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