Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells.

Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells.

Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the pluripotency and differentiation of embryonic stem (ES) cells. The recent demonstration that 5-methylcytosine (5-mC) may be further modified to 5-hydroxymethylcytosine (5-hmC) in ES cells has revealed a...

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Main Authors: Keith E Szulwach, Xuekun Li, Yujing Li, Chun-Xiao Song, Ji Woong Han, SangSung Kim, Sandeep Namburi, Karen Hermetz, Julie J Kim, M Katharine Rudd, Young-Sup Yoon, Bing Ren, Chuan He, Peng Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002154&type=printable
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