Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children
Immunoglobulin A (IgA) deficiency is the most common primary deficiency. We aimed to define the prevalence of IgA deficiency among healthy school children in Turkey and the differences between geographical regions. Blood samples were collected from 20,331 healthy school children from all regi...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2011-08-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1786 |
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| author | Bilkay Baştürk Sinan Sari Arzu Aral Buket Dalgiç |
| author_facet | Bilkay Baştürk Sinan Sari Arzu Aral Buket Dalgiç |
| author_sort | Bilkay Baştürk |
| collection | DOAJ |
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Immunoglobulin A (IgA) deficiency is the most common primary deficiency. We aimed to define the prevalence of IgA deficiency among healthy school children in Turkey and the differences between geographical regions. Blood samples were collected from 20,331 healthy school children from all regions across Turkey. The serum IgA levels were tested through nephelometric method, and all 108 samples with IgA levels lower than 5 g/L were tested through ELISA for IgG and IgM levels. All IgG and IgM values were within the normal range in all cases, and no concomitant deficiency was observed. Our study results showed that the selective IgA deficiency incidence was 0.52% (1:188). The highest incidence, of 1:128.7, was observed in children from the Marmara region; the Black Sea Region levels (1:132.7) were lower, and the Mediterranean levels (1:365.7) were the lowest.
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| format | Article |
| id | doaj-art-d56a0931393c4e05a5de1d59665ffbb2 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2011-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-d56a0931393c4e05a5de1d59665ffbb22025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212011-08-01534Prevalence of selective immunoglobulin A deficiency in healthy Turkish school childrenBilkay Baştürk0Sinan SariArzu AralBuket DalgiçDepartment of Immunology, Gazi University Faculty of Medicine, Ankara, Turkey. Immunoglobulin A (IgA) deficiency is the most common primary deficiency. We aimed to define the prevalence of IgA deficiency among healthy school children in Turkey and the differences between geographical regions. Blood samples were collected from 20,331 healthy school children from all regions across Turkey. The serum IgA levels were tested through nephelometric method, and all 108 samples with IgA levels lower than 5 g/L were tested through ELISA for IgG and IgM levels. All IgG and IgM values were within the normal range in all cases, and no concomitant deficiency was observed. Our study results showed that the selective IgA deficiency incidence was 0.52% (1:188). The highest incidence, of 1:128.7, was observed in children from the Marmara region; the Black Sea Region levels (1:132.7) were lower, and the Mediterranean levels (1:365.7) were the lowest. https://turkjpediatr.org/article/view/1786 |
| spellingShingle | Bilkay Baştürk Sinan Sari Arzu Aral Buket Dalgiç Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children The Turkish Journal of Pediatrics |
| title | Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children |
| title_full | Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children |
| title_fullStr | Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children |
| title_full_unstemmed | Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children |
| title_short | Prevalence of selective immunoglobulin A deficiency in healthy Turkish school children |
| title_sort | prevalence of selective immunoglobulin a deficiency in healthy turkish school children |
| url | https://turkjpediatr.org/article/view/1786 |
| work_keys_str_mv | AT bilkaybasturk prevalenceofselectiveimmunoglobulinadeficiencyinhealthyturkishschoolchildren AT sinansari prevalenceofselectiveimmunoglobulinadeficiencyinhealthyturkishschoolchildren AT arzuaral prevalenceofselectiveimmunoglobulinadeficiencyinhealthyturkishschoolchildren AT buketdalgic prevalenceofselectiveimmunoglobulinadeficiencyinhealthyturkishschoolchildren |