Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer

Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer

Background Higher cytotoxic T lymphocyte (CTL) numbers in the tumor microenvironment (TME) predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and positive long-term outcomes in triple-negative breast cancer (TNBC). pCR to NAC is achieved only in 30–40% of patients. The comb...

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Main Authors: Jessica Young, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Sacha Gnjatic, Jianming Wang, Shipra Gandhi, Kristopher Attwood, Tracey O’Connor, Kazuaki Takabe, Victoria Fitzpatrick, Eduardo Cortes Gomez, Stephen Edge, Janine Miller, Ronald T Slomba, Ellis G Levine, Sinem Ozbey, Giorgio Ioannou, Cayla Janes, Igor De Souza, Vladimir Roudko, Prasanna Kumar, Suresh Kalathil, Helen Cappuccino
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e010058.full
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