The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma
Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to b...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2017/2692604 |
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| author | Anthony Paulo Sunjaya Angela Felicia Sunjaya Sukmawati Tansil Tan |
| author_facet | Anthony Paulo Sunjaya Angela Felicia Sunjaya Sukmawati Tansil Tan |
| author_sort | Anthony Paulo Sunjaya |
| collection | DOAJ |
| description | Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery. |
| format | Article |
| id | doaj-art-d568ad3570ef4e169fde9b85598888ab |
| institution | OA Journals |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-d568ad3570ef4e169fde9b85598888ab2025-08-20T02:19:38ZengWileyJournal of Skin Cancer2090-29052090-29132017-01-01201710.1155/2017/26926042692604The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell CarcinomaAnthony Paulo Sunjaya0Angela Felicia Sunjaya1Sukmawati Tansil Tan2Faculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No. 1, Jakarta 11440, IndonesiaFaculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No. 1, Jakarta 11440, IndonesiaFaculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No. 1, Jakarta 11440, IndonesiaBasal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.http://dx.doi.org/10.1155/2017/2692604 |
| spellingShingle | Anthony Paulo Sunjaya Angela Felicia Sunjaya Sukmawati Tansil Tan The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma Journal of Skin Cancer |
| title | The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma |
| title_full | The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma |
| title_fullStr | The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma |
| title_full_unstemmed | The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma |
| title_short | The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma |
| title_sort | use of berep4 immunohistochemistry staining for detection of basal cell carcinoma |
| url | http://dx.doi.org/10.1155/2017/2692604 |
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