Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Abstract To investigate the mechanisms behind the worsening of acute lung injury (ALI) in obesity, transcriptomic sequencing is performed, and significantly reduced mRNA levels of Aconitate Decarboxylase 1 (ACOD1) in the lung tissue of high‐fat diet (HFD) mice are found. Clinical samples are collect...

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Main Authors: Jingyue Ma, Yichan Ao, Zhen Yue, Zhiqiao Wang, Xiangyu Hou, Hongbin Li, Hanbing Wang, Siqing Luo, Jianyu He, Zikun Duan, Ling Liu, Ke Wei
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
ACOD1
ARDS
lung injury
macrophages
obesity
Online Access:https://doi.org/10.1002/advs.202413546
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