С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication
It is known that reactive oxygen species are important in the development of alcoholic myopathy, and their suppression by C60 fullerene nanoparticles, as potent antioxidants, is opening up a new direction for their use in biomedical nanotechnology. Here, for the first time, the biomechanical and bio...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/jnt/9916259 |
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| author | Olexandr Motuziuk Dmytro Nozdrenko Svitlana Prylutska Yurii Osyp Kateryna Bogutska Olena Dmytrotsa Yuriy Prylutskyy Peter Scharff Uwe Ritter |
| author_facet | Olexandr Motuziuk Dmytro Nozdrenko Svitlana Prylutska Yurii Osyp Kateryna Bogutska Olena Dmytrotsa Yuriy Prylutskyy Peter Scharff Uwe Ritter |
| author_sort | Olexandr Motuziuk |
| collection | DOAJ |
| description | It is known that reactive oxygen species are important in the development of alcoholic myopathy, and their suppression by C60 fullerene nanoparticles, as potent antioxidants, is opening up a new direction for their use in biomedical nanotechnology. Here, for the first time, the biomechanical and biochemical parameters of the functioning of rat muscle soleus under alcohol intoxication at 3, 6, and 9 months were analyzed. C60 fullerene, as a therapeutic nanoagent, at an oral dose of 1 mg kg−1 was used along with alcohol throughout the experiment. The findings indicate that significant dysfunctions develop in the rat muscle soleus after chronic alcohol intoxication. However, these dysfunctions are significantly reduced due to exposure to C60 fullerenes, particularly with prolonged alcoholization of animals (9 months) and the development of high-intensity fatigue processes. |
| format | Article |
| id | doaj-art-d5536668de404b7ea903897a4f8da399 |
| institution | Kabale University |
| issn | 1687-9511 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-d5536668de404b7ea903897a4f8da3992025-08-20T03:55:59ZengWileyJournal of Nanotechnology1687-95112025-01-01202510.1155/jnt/9916259С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol IntoxicationOlexandr Motuziuk0Dmytro Nozdrenko1Svitlana Prylutska2Yurii Osyp3Kateryna Bogutska4Olena Dmytrotsa5Yuriy Prylutskyy6Peter Scharff7Uwe Ritter8Department of Biophysics and NeurobiologyDepartment of Biophysics and NeurobiologyDepartment of PhysiologyDepartment of Human and Animal PhysiologyDepartment of Biophysics and NeurobiologyDepartment of Human and Animal PhysiologyDepartment of Biophysics and NeurobiologyInstitute of Chemistry and BiotechnologyInstitute of Chemistry and BiotechnologyIt is known that reactive oxygen species are important in the development of alcoholic myopathy, and their suppression by C60 fullerene nanoparticles, as potent antioxidants, is opening up a new direction for their use in biomedical nanotechnology. Here, for the first time, the biomechanical and biochemical parameters of the functioning of rat muscle soleus under alcohol intoxication at 3, 6, and 9 months were analyzed. C60 fullerene, as a therapeutic nanoagent, at an oral dose of 1 mg kg−1 was used along with alcohol throughout the experiment. The findings indicate that significant dysfunctions develop in the rat muscle soleus after chronic alcohol intoxication. However, these dysfunctions are significantly reduced due to exposure to C60 fullerenes, particularly with prolonged alcoholization of animals (9 months) and the development of high-intensity fatigue processes.http://dx.doi.org/10.1155/jnt/9916259 |
| spellingShingle | Olexandr Motuziuk Dmytro Nozdrenko Svitlana Prylutska Yurii Osyp Kateryna Bogutska Olena Dmytrotsa Yuriy Prylutskyy Peter Scharff Uwe Ritter С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication Journal of Nanotechnology |
| title | С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication |
| title_full | С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication |
| title_fullStr | С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication |
| title_full_unstemmed | С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication |
| title_short | С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication |
| title_sort | с60 fullerenes diminish dysfunctions in rat muscle soleus with chronic alcohol intoxication |
| url | http://dx.doi.org/10.1155/jnt/9916259 |
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