Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone

This prospective 2-year, single-center, randomized, placebo-controlled, open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate (TU) treatment on bone mineral density (BMD) and biochemical markers of bone turnover in elderly male osteoporosis with low se...

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Main Authors: Yan-Jiao Wang, Jun-Kun Zhan, Wu Huang, Yi Wang, Yuan Liu, Sha Wang, Pan Tan, Zhi-Yong Tang, You-Shuo Liu
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2013/570413
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author Yan-Jiao Wang
Jun-Kun Zhan
Wu Huang
Yi Wang
Yuan Liu
Sha Wang
Pan Tan
Zhi-Yong Tang
You-Shuo Liu
author_facet Yan-Jiao Wang
Jun-Kun Zhan
Wu Huang
Yi Wang
Yuan Liu
Sha Wang
Pan Tan
Zhi-Yong Tang
You-Shuo Liu
author_sort Yan-Jiao Wang
collection DOAJ
description This prospective 2-year, single-center, randomized, placebo-controlled, open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate (TU) treatment on bone mineral density (BMD) and biochemical markers of bone turnover in elderly male osteoporosis with low serum testosterone. A total of 186 elderly male osteoporosis patients with low serum testosterone were randomized into three groups: low-dose TU (20 mg, per day), standard-dose TU (40 mg, per day), and placebo group with a 24-month followup. Since the 6th month in standard-dose TU group or since the 12th month followup in low-dose TU group and throughout the study, lumbar spine and femoral neck BMD and serum levels of free testosterone, estradiol, and bone alkaline phosphatase significantly increased. There were no significant differences between groups of low-dose TU and standard dose TU in the percentage of changes of these data since the 18th month followup and throughout the study. No side effects on prostate glands including prostate specific antigen were found. In conclusion, low-dose TU (20 mg, per day) may be a cost effective and safe protocol for treating elderly male osteoporosis with low serum testosterone.
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institution Kabale University
issn 1687-8337
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language English
publishDate 2013-01-01
publisher Wiley
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series International Journal of Endocrinology
spelling doaj-art-d5508a6cca754bcca83edf859497fac62025-02-03T05:43:51ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/570413570413Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum TestosteroneYan-Jiao Wang0Jun-Kun Zhan1Wu Huang2Yi Wang3Yuan Liu4Sha Wang5Pan Tan6Zhi-Yong Tang7You-Shuo Liu8Geriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaGeriatric Department of the Second Xiang-Ya Hospital, Institute of Aging and Geriatric Research, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, ChinaThis prospective 2-year, single-center, randomized, placebo-controlled, open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate (TU) treatment on bone mineral density (BMD) and biochemical markers of bone turnover in elderly male osteoporosis with low serum testosterone. A total of 186 elderly male osteoporosis patients with low serum testosterone were randomized into three groups: low-dose TU (20 mg, per day), standard-dose TU (40 mg, per day), and placebo group with a 24-month followup. Since the 6th month in standard-dose TU group or since the 12th month followup in low-dose TU group and throughout the study, lumbar spine and femoral neck BMD and serum levels of free testosterone, estradiol, and bone alkaline phosphatase significantly increased. There were no significant differences between groups of low-dose TU and standard dose TU in the percentage of changes of these data since the 18th month followup and throughout the study. No side effects on prostate glands including prostate specific antigen were found. In conclusion, low-dose TU (20 mg, per day) may be a cost effective and safe protocol for treating elderly male osteoporosis with low serum testosterone.http://dx.doi.org/10.1155/2013/570413
spellingShingle Yan-Jiao Wang
Jun-Kun Zhan
Wu Huang
Yi Wang
Yuan Liu
Sha Wang
Pan Tan
Zhi-Yong Tang
You-Shuo Liu
Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
International Journal of Endocrinology
title Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
title_full Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
title_fullStr Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
title_full_unstemmed Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
title_short Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
title_sort effects of low dose testosterone undecanoate treatment on bone mineral density and bone turnover markers in elderly male osteoporosis with low serum testosterone
url http://dx.doi.org/10.1155/2013/570413
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