Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications
Abstract This research focuses on synthesizing bioactive glass nanoparticles with different phosphate concentrations to evaluate their physicochemical characteristics and explore their biomedical potential. The nanoparticles were fabricated by melting a mixture of silica, calcium oxide, sodium oxide...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | BMC Chemistry |
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| Online Access: | https://doi.org/10.1186/s13065-025-01543-w |
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| author | Wael M. Aboulthana Sahar M. Mousa Gehan T. El-Bassyouni Esmat M. A. Hamzawy Amal G. Hussien M. Eltohamy |
| author_facet | Wael M. Aboulthana Sahar M. Mousa Gehan T. El-Bassyouni Esmat M. A. Hamzawy Amal G. Hussien M. Eltohamy |
| author_sort | Wael M. Aboulthana |
| collection | DOAJ |
| description | Abstract This research focuses on synthesizing bioactive glass nanoparticles with different phosphate concentrations to evaluate their physicochemical characteristics and explore their biomedical potential. The nanoparticles were fabricated by melting a mixture of silica, calcium oxide, sodium oxide, and ammonium dihydrogen phosphate at 1450 °C, followed by ball milling to obtain the optimal particle size distribution. The study systematically investigated the effect of phosphate content on the nanoparticles’ structural properties and bioactive performance. Advanced characterization methods; such as XRD, FTIR, DTA, and FE-SEM–EDX were used to examine structural stability and phosphate-induced surface alterations. In vitro assays revealed dose-dependent antioxidant, anti-diabetic, anti-Alzheimer’s, anti-arthritic, and anti-inflammatory activities, with higher phosphate content enhancing bioactivity. Results demonstrated enhanced radical scavenging and enzyme inhibition in samples with higher phosphate levels. These findings suggest that phosphate-doped bioactive glass nanoparticles hold significant promise for therapeutic applications. The research advances the understanding of how synthesis parameters influence bioactivity, providing valuable insights for designing next-generation biomedical materials. |
| format | Article |
| id | doaj-art-d54d7a50ce1c4c8b899b60f89e49772a |
| institution | DOAJ |
| issn | 2661-801X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj-art-d54d7a50ce1c4c8b899b60f89e49772a2025-08-20T03:22:46ZengBMCBMC Chemistry2661-801X2025-06-0119111710.1186/s13065-025-01543-wPreparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applicationsWael M. Aboulthana0Sahar M. Mousa1Gehan T. El-Bassyouni2Esmat M. A. Hamzawy3Amal G. Hussien4M. Eltohamy5Biochemistry Department, Biotechnology Research Institute, National Research CentreInorganic Chemistry Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research CentreRefractories, Ceramics and Building Materials Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research CentreGlass Research Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research CentreBiochemistry Department, Biotechnology Research Institute, National Research CentreGlass Research Department, Advanced Materials Technology and Mineral Resources Research Institute, National Research CentreAbstract This research focuses on synthesizing bioactive glass nanoparticles with different phosphate concentrations to evaluate their physicochemical characteristics and explore their biomedical potential. The nanoparticles were fabricated by melting a mixture of silica, calcium oxide, sodium oxide, and ammonium dihydrogen phosphate at 1450 °C, followed by ball milling to obtain the optimal particle size distribution. The study systematically investigated the effect of phosphate content on the nanoparticles’ structural properties and bioactive performance. Advanced characterization methods; such as XRD, FTIR, DTA, and FE-SEM–EDX were used to examine structural stability and phosphate-induced surface alterations. In vitro assays revealed dose-dependent antioxidant, anti-diabetic, anti-Alzheimer’s, anti-arthritic, and anti-inflammatory activities, with higher phosphate content enhancing bioactivity. Results demonstrated enhanced radical scavenging and enzyme inhibition in samples with higher phosphate levels. These findings suggest that phosphate-doped bioactive glass nanoparticles hold significant promise for therapeutic applications. The research advances the understanding of how synthesis parameters influence bioactivity, providing valuable insights for designing next-generation biomedical materials.https://doi.org/10.1186/s13065-025-01543-wAntioxidant and anti-inflammatory effectsBioactive glass nanoparticlesBiomedical applicationsIn vitro bioactivityPhosphate doping |
| spellingShingle | Wael M. Aboulthana Sahar M. Mousa Gehan T. El-Bassyouni Esmat M. A. Hamzawy Amal G. Hussien M. Eltohamy Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications BMC Chemistry Antioxidant and anti-inflammatory effects Bioactive glass nanoparticles Biomedical applications In vitro bioactivity Phosphate doping |
| title | Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| title_full | Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| title_fullStr | Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| title_full_unstemmed | Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| title_short | Preparation, characterization and in vitro evaluation of phosphate-doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| title_sort | preparation characterization and in vitro evaluation of phosphate doped bioactive glass nanoparticles as promising candidates for therapeutic applications |
| topic | Antioxidant and anti-inflammatory effects Bioactive glass nanoparticles Biomedical applications In vitro bioactivity Phosphate doping |
| url | https://doi.org/10.1186/s13065-025-01543-w |
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