Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model
Purpose. To evaluate the effects of the surgical ligation of the ureter in different locations on the kidney over time in the rat model. Methods. A total of 155 rats were enrolled and randomly divided into the case (n = 150) and control (n = 5) groups. The case group included three separate groups (...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2024/6611081 |
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| author | Abdolreza Mohammadi Leila Zareian Baghdadabad Parisa Zahmatkesh Hedieh Moradi Tabriz Alireza Khajavi Gholamreza Mesbah Parsa Nikoofar Seyed Mohammad Kazem Aghamir |
| author_facet | Abdolreza Mohammadi Leila Zareian Baghdadabad Parisa Zahmatkesh Hedieh Moradi Tabriz Alireza Khajavi Gholamreza Mesbah Parsa Nikoofar Seyed Mohammad Kazem Aghamir |
| author_sort | Abdolreza Mohammadi |
| collection | DOAJ |
| description | Purpose. To evaluate the effects of the surgical ligation of the ureter in different locations on the kidney over time in the rat model. Methods. A total of 155 rats were enrolled and randomly divided into the case (n = 150) and control (n = 5) groups. The case group included three separate groups (fifty rats in each group) that underwent surgical ureteral ligation at the proximal, middle, and distal ureter. The laboratory tests, and tumor necrosis factor α (TNF-α), were measured in groups. The pathological evaluation for glomerular changes, tubular dilation, interstitial fibrosis, and interstitial infiltration of the inflammatory cells following the obstruction was performed (severity of tubular atrophy categorized too mild (+), moderate (++), and severe (+++)). To compare the continuous variables between the groups and between the measurement times, the analysis of variance (ANOVA) was used. Results. Our results revealed that the creatinine four weeks after the obstruction was significantly higher in the proximal group obstruction (p value: 0.046). The three groups had no significant differences regarding urine creatinine, serum sodium, and serum TNF (p value: 0.261). Obstruction did not change the glomerular morphology in three intervention groups after six weeks. The commencing of severe tubular atrophy in proximal, middle, and distal ureteral obstruction was at weeks three, four, and six, respectively. Conclusion. The location of ureteral obstruction is also crucial in deciding to intervene to relieve the complete ureteral obstruction. Severe tubular damage occurs in weeks three, four, and six in proximal, middle, and distal ureteral obstruction, respectively. |
| format | Article |
| id | doaj-art-d54cd93274454851a889dafcda415675 |
| institution | Kabale University |
| issn | 1687-6377 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-d54cd93274454851a889dafcda4156752025-08-20T03:24:35ZengWileyAdvances in Urology1687-63772024-01-01202410.1155/2024/6611081Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat ModelAbdolreza Mohammadi0Leila Zareian Baghdadabad1Parisa Zahmatkesh2Hedieh Moradi Tabriz3Alireza Khajavi4Gholamreza Mesbah5Parsa Nikoofar6Seyed Mohammad Kazem Aghamir7Urology Research CenterUrology Research CenterUrology Research CenterDepartment of PathologyStudent Research CommitteeUrology Research CenterDepartment of UrologyUrology Research CenterPurpose. To evaluate the effects of the surgical ligation of the ureter in different locations on the kidney over time in the rat model. Methods. A total of 155 rats were enrolled and randomly divided into the case (n = 150) and control (n = 5) groups. The case group included three separate groups (fifty rats in each group) that underwent surgical ureteral ligation at the proximal, middle, and distal ureter. The laboratory tests, and tumor necrosis factor α (TNF-α), were measured in groups. The pathological evaluation for glomerular changes, tubular dilation, interstitial fibrosis, and interstitial infiltration of the inflammatory cells following the obstruction was performed (severity of tubular atrophy categorized too mild (+), moderate (++), and severe (+++)). To compare the continuous variables between the groups and between the measurement times, the analysis of variance (ANOVA) was used. Results. Our results revealed that the creatinine four weeks after the obstruction was significantly higher in the proximal group obstruction (p value: 0.046). The three groups had no significant differences regarding urine creatinine, serum sodium, and serum TNF (p value: 0.261). Obstruction did not change the glomerular morphology in three intervention groups after six weeks. The commencing of severe tubular atrophy in proximal, middle, and distal ureteral obstruction was at weeks three, four, and six, respectively. Conclusion. The location of ureteral obstruction is also crucial in deciding to intervene to relieve the complete ureteral obstruction. Severe tubular damage occurs in weeks three, four, and six in proximal, middle, and distal ureteral obstruction, respectively.http://dx.doi.org/10.1155/2024/6611081 |
| spellingShingle | Abdolreza Mohammadi Leila Zareian Baghdadabad Parisa Zahmatkesh Hedieh Moradi Tabriz Alireza Khajavi Gholamreza Mesbah Parsa Nikoofar Seyed Mohammad Kazem Aghamir Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model Advances in Urology |
| title | Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model |
| title_full | Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model |
| title_fullStr | Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model |
| title_full_unstemmed | Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model |
| title_short | Effects of the Surgical Ligation of the Ureter in Different Locations on the Kidney over Time in the Rat Model |
| title_sort | effects of the surgical ligation of the ureter in different locations on the kidney over time in the rat model |
| url | http://dx.doi.org/10.1155/2024/6611081 |
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