Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1

Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1

Abstract Background The clinical response rate to immune checkpoint blockade (ICB) therapy in melanoma remains low, despite its widespread use. Circular non-coding RNAs (circRNAs) are known to play a crucial role in cancer progression and may be a key factor limiting the effectiveness of ICB treatme...

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Bibliographic Details
Main Authors: Xin Zang, Xiao-Yu He, Cheng-Mei Xiao, Qing Lin, Meng-Yue Wang, Cheng-Yan Liu, Ling-Yi Kong, Zhong Chen, Yuan-Zheng Xia
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Molecular Cancer
Subjects:
Melanoma
ICB therapy
CircPIAS1
Novel peptides
Immunogenic ferroptosis
STAT1
Online Access:https://doi.org/10.1186/s12943-024-02124-6
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