Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study
Abstract Background Chronic kidney disease (CKD) is a serious health issue. The kidney's parenchymal tissue stiffens as a result of the pathological changes related to CKD as glomerulosclerosis and interstitial fibrosis. Shear wave elastography (SWE) is a noninvasive ultrasonic method that meas...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-03-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-025-01438-9 |
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| author | Shaimaa Sayed Fatina I. Fadel Sally Emad-Eldin Rasha E. Galal Hend Mohamed Reham O. Mohmoud |
| author_facet | Shaimaa Sayed Fatina I. Fadel Sally Emad-Eldin Rasha E. Galal Hend Mohamed Reham O. Mohmoud |
| author_sort | Shaimaa Sayed |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD) is a serious health issue. The kidney's parenchymal tissue stiffens as a result of the pathological changes related to CKD as glomerulosclerosis and interstitial fibrosis. Shear wave elastography (SWE) is a noninvasive ultrasonic method that measures stiffness of the tissues. We aimed to assess kidney parenchymal tissue stiffness in different stages of pediatric CKD using SWE. We conducted a case–control study included 58 children with CKD stage 3, 4, 5 as the case group. Twenty-two age- and sex-matched healthy children were included as the control group. We obtained baseline data from the patients' medical files. The mean values of SWE readings of the kidney cortex (upper pole, lower pole and middle zone of both kidneys) were taken. Correlations between SWE measurements and CKD stages were performed. Results Regarding the case group, their mean age was 9.3 ±2.43 years. All measurements of SWE of both kidneys were significantly increased than the control group. With the advance of CKD stages, the SWE values increased. Worsening of the kidney function tests and decline of the eGFR are associated with increased kidney tissue stiffness and increase in SWE values. Conclusions SWE is a feasible noninvasive method to assess kidney parenchymal tissue stiffness in children with CKD. Kidney tissue stiffness increases with advance of the CKD stage. SWE can help in identification of moderate and late stages of CKD. |
| format | Article |
| id | doaj-art-d54a77b27254411fb4ddffd4e2e4b4dc |
| institution | DOAJ |
| issn | 2090-4762 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj-art-d54a77b27254411fb4ddffd4e2e4b4dc2025-08-20T02:59:24ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622025-03-0156111210.1186/s43055-025-01438-9Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control studyShaimaa Sayed0Fatina I. Fadel1Sally Emad-Eldin2Rasha E. Galal3Hend Mohamed4Reham O. Mohmoud5Faculty of Medicine, (Pediatric Department), Cairo UniversityFaculty of Medicine, (Pediatric Department), Cairo UniversityFaculty of Medicine, (Radiology Department), Cairo UniversityFaculty of Medicine, (Pediatric Department), Cairo UniversityFaculty of Medicine, (Pediatric Department), Cairo UniversityFaculty of Medicine, (Radiology Department), Cairo UniversityAbstract Background Chronic kidney disease (CKD) is a serious health issue. The kidney's parenchymal tissue stiffens as a result of the pathological changes related to CKD as glomerulosclerosis and interstitial fibrosis. Shear wave elastography (SWE) is a noninvasive ultrasonic method that measures stiffness of the tissues. We aimed to assess kidney parenchymal tissue stiffness in different stages of pediatric CKD using SWE. We conducted a case–control study included 58 children with CKD stage 3, 4, 5 as the case group. Twenty-two age- and sex-matched healthy children were included as the control group. We obtained baseline data from the patients' medical files. The mean values of SWE readings of the kidney cortex (upper pole, lower pole and middle zone of both kidneys) were taken. Correlations between SWE measurements and CKD stages were performed. Results Regarding the case group, their mean age was 9.3 ±2.43 years. All measurements of SWE of both kidneys were significantly increased than the control group. With the advance of CKD stages, the SWE values increased. Worsening of the kidney function tests and decline of the eGFR are associated with increased kidney tissue stiffness and increase in SWE values. Conclusions SWE is a feasible noninvasive method to assess kidney parenchymal tissue stiffness in children with CKD. Kidney tissue stiffness increases with advance of the CKD stage. SWE can help in identification of moderate and late stages of CKD.https://doi.org/10.1186/s43055-025-01438-9Shear wave elastographyKidney parenchymal stiffnessPediatricChronic kidney disease |
| spellingShingle | Shaimaa Sayed Fatina I. Fadel Sally Emad-Eldin Rasha E. Galal Hend Mohamed Reham O. Mohmoud Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study The Egyptian Journal of Radiology and Nuclear Medicine Shear wave elastography Kidney parenchymal stiffness Pediatric Chronic kidney disease |
| title | Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study |
| title_full | Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study |
| title_fullStr | Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study |
| title_full_unstemmed | Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study |
| title_short | Assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography: a case–control study |
| title_sort | assessment of kidney tissue stiffness in different stages of pediatric chronic kidney disease using shear wave elastography a case control study |
| topic | Shear wave elastography Kidney parenchymal stiffness Pediatric Chronic kidney disease |
| url | https://doi.org/10.1186/s43055-025-01438-9 |
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