Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review
Abstract Background Exposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in chronic endogenous exposur...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-04208-x |
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| author | Yan Cai Qingqing You Weina Jiang Xuyan Liu Leping Shao |
| author_facet | Yan Cai Qingqing You Weina Jiang Xuyan Liu Leping Shao |
| author_sort | Yan Cai |
| collection | DOAJ |
| description | Abstract Background Exposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in chronic endogenous exposure to metal ions. The pathophysiological mechanisms underlying implant-related complications and their clinical implications have not been fully elucidated. Case presentation We present a case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome coexisting with IgA nephropathy (IgAN) in the context of dental amalgam exposure. Following amalgam placement, the patient developed palmoplantar pustulosis (PPP) and sternoclavicular arthritis, with a subsequent diagnosis of IgAN. Notably, all the clinical manifestations were markedly resolved after amalgam removal. Conclusion This case suggests a potential link between SAPHO syndrome, IgAN, and dental amalgam exposure. To our knowledge, this is the first reported case linking these conditions. Further studies are needed to elucidate the mechanisms and clinical implications of metal-induced autoimmune or inflammatory responses. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-d54955c1a2364385ba9232bfa2bf5914 |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-d54955c1a2364385ba9232bfa2bf59142025-08-20T03:47:24ZengBMCBMC Nephrology1471-23692025-06-012611910.1186/s12882-025-04208-xDental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature reviewYan Cai0Qingqing You1Weina Jiang2Xuyan Liu3Leping Shao4Department of Nephrology, Qingdao Municipal Hospital, University of Health and Rehabilitation SciencesDepartment of Nephrology, Qingdao Municipal Hospital, University of Health and Rehabilitation SciencesDepartment of Pathology, Qingdao Municipal Hospital, University of Health and Rehabilitation SciencesDepartment of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao UniversityDepartment of Nephrology (Fujian Provincial Clinical Research Center for Glomerular Nephritis), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Background Exposure to metals is associated with adverse health effects, including multiorgan damage and dysregulation of systemic immune responses. The increasing use of metallic implants in humans, such as dental materials and orthopedic devices, has resulted in chronic endogenous exposure to metal ions. The pathophysiological mechanisms underlying implant-related complications and their clinical implications have not been fully elucidated. Case presentation We present a case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome coexisting with IgA nephropathy (IgAN) in the context of dental amalgam exposure. Following amalgam placement, the patient developed palmoplantar pustulosis (PPP) and sternoclavicular arthritis, with a subsequent diagnosis of IgAN. Notably, all the clinical manifestations were markedly resolved after amalgam removal. Conclusion This case suggests a potential link between SAPHO syndrome, IgAN, and dental amalgam exposure. To our knowledge, this is the first reported case linking these conditions. Further studies are needed to elucidate the mechanisms and clinical implications of metal-induced autoimmune or inflammatory responses. Clinical trial number Not applicable.https://doi.org/10.1186/s12882-025-04208-xDental amalgamMetalSAPHO syndromeIgA nephropathy |
| spellingShingle | Yan Cai Qingqing You Weina Jiang Xuyan Liu Leping Shao Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review BMC Nephrology Dental amalgam Metal SAPHO syndrome IgA nephropathy |
| title | Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review |
| title_full | Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review |
| title_fullStr | Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review |
| title_full_unstemmed | Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review |
| title_short | Dental amalgam associated with SAPHO syndrome and IgA nephropathy: a case report and literature review |
| title_sort | dental amalgam associated with sapho syndrome and iga nephropathy a case report and literature review |
| topic | Dental amalgam Metal SAPHO syndrome IgA nephropathy |
| url | https://doi.org/10.1186/s12882-025-04208-x |
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