Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia
Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/6452843 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683910535938048 |
|---|---|
| author | Vikrant Singh Bhar Vasudha Gupta Mahak Sharma Rishi Dhawan Shilpi Modi Mona Vijyaran |
| author_facet | Vikrant Singh Bhar Vasudha Gupta Mahak Sharma Rishi Dhawan Shilpi Modi Mona Vijyaran |
| author_sort | Vikrant Singh Bhar |
| collection | DOAJ |
| description | Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Flowcytometric immunophenotyping confirmed the monocytic lineage of cells, whereas small lymphocytes showed the immunophenotype consistent with chronic lymphocytic leukemia (CLL). The final diagnosis was made as acute monoblastic leukemia with associated CLL. This is a rare case scenario, and this highlights the importance of careful morphological examination and flowcytometric immunophenotyping in the exact characterization of hematopoietic malignancies. |
| format | Article |
| id | doaj-art-d54026909d3d4bab9aae1d4aa4e6bcc2 |
| institution | DOAJ |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d54026909d3d4bab9aae1d4aa4e6bcc22025-08-20T03:23:38ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/64528436452843Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic LeukemiaVikrant Singh Bhar0Vasudha Gupta1Mahak Sharma2Rishi Dhawan3Shilpi Modi4Mona Vijyaran5Associate Consultant, Department of Haematopathology, Artemis Hospitals, Gurgaon, IndiaAssociate Consultant, Department of Haematopathology, Artemis Hospitals, Gurgaon, IndiaSenior Resident, Department of Haematopathology, Artemis Hospitals, Gurgaon, IndiaAssistant Professor, Department of Hematology, AIIMS, New Delhi, IndiaAssociate Consultant, Department of Histopathology, Artemis Hospitals, Gurgaon, IndiaAssociate Consultant, Department of Hematooncology, Artemis Hospitals, Gurgaon, IndiaAcute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Flowcytometric immunophenotyping confirmed the monocytic lineage of cells, whereas small lymphocytes showed the immunophenotype consistent with chronic lymphocytic leukemia (CLL). The final diagnosis was made as acute monoblastic leukemia with associated CLL. This is a rare case scenario, and this highlights the importance of careful morphological examination and flowcytometric immunophenotyping in the exact characterization of hematopoietic malignancies.http://dx.doi.org/10.1155/2018/6452843 |
| spellingShingle | Vikrant Singh Bhar Vasudha Gupta Mahak Sharma Rishi Dhawan Shilpi Modi Mona Vijyaran Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia Case Reports in Hematology |
| title | Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia |
| title_full | Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia |
| title_fullStr | Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia |
| title_short | Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia |
| title_sort | rare coexistence of acute monoblastic leukemia with chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2018/6452843 |
| work_keys_str_mv | AT vikrantsinghbhar rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia AT vasudhagupta rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia AT mahaksharma rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia AT rishidhawan rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia AT shilpimodi rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia AT monavijyaran rarecoexistenceofacutemonoblasticleukemiawithchroniclymphocyticleukemia |