S100A12 in Digestive Diseases and Health: A Scoping Review
Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is hi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/2868373 |
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| author | Alexandre Carvalho Jacky Lu Jamisha D. Francis Rebecca E. Moore Kathryn P. Haley Ryan S. Doster Steven D. Townsend Jeremiah G. Johnson Steven M. Damo Jennifer A. Gaddy |
| author_facet | Alexandre Carvalho Jacky Lu Jamisha D. Francis Rebecca E. Moore Kathryn P. Haley Ryan S. Doster Steven D. Townsend Jeremiah G. Johnson Steven M. Damo Jennifer A. Gaddy |
| author_sort | Alexandre Carvalho |
| collection | DOAJ |
| description | Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases. |
| format | Article |
| id | doaj-art-d53e0e7db02c482fb268f82de0af1f1c |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d53e0e7db02c482fb268f82de0af1f1c2025-08-20T03:19:42ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/28683732868373S100A12 in Digestive Diseases and Health: A Scoping ReviewAlexandre Carvalho0Jacky Lu1Jamisha D. Francis2Rebecca E. Moore3Kathryn P. Haley4Ryan S. Doster5Steven D. Townsend6Jeremiah G. Johnson7Steven M. Damo8Jennifer A. Gaddy9Internal Medicine Program, St. Joseph Mercy Hospital, Ann Arbor, Michigan, USADepartment of Pathology, Microbiology, And Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USADepartment of Pathology, Microbiology, And Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USADepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USADepartment of Biomedical Sciences, Grand Valley State University, Allendale, Michigan, USADepartment of Pathology, Microbiology, And Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USADepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USADepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USADepartment of Life and Physical Sciences, Fisk University, Nashville, Tennessee, USADepartment of Pathology, Microbiology, And Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USACalgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens. S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation. We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health. Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers. Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases.http://dx.doi.org/10.1155/2020/2868373 |
| spellingShingle | Alexandre Carvalho Jacky Lu Jamisha D. Francis Rebecca E. Moore Kathryn P. Haley Ryan S. Doster Steven D. Townsend Jeremiah G. Johnson Steven M. Damo Jennifer A. Gaddy S100A12 in Digestive Diseases and Health: A Scoping Review Gastroenterology Research and Practice |
| title | S100A12 in Digestive Diseases and Health: A Scoping Review |
| title_full | S100A12 in Digestive Diseases and Health: A Scoping Review |
| title_fullStr | S100A12 in Digestive Diseases and Health: A Scoping Review |
| title_full_unstemmed | S100A12 in Digestive Diseases and Health: A Scoping Review |
| title_short | S100A12 in Digestive Diseases and Health: A Scoping Review |
| title_sort | s100a12 in digestive diseases and health a scoping review |
| url | http://dx.doi.org/10.1155/2020/2868373 |
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