Ameliorative effect of Borago officinalis L extract on sperm parameters, testosterone level in a streptozotocin-induced mouse model of diabetes
Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Kurdistan University of Medical Sciences
2024-11-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-8161-en.pdf |
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| Summary: | Background and Aim: Diabetes mellitus (DM) is a common metabolic disease characterized by high blood sugar levels. It is well known that men with diabetes frequently experience reproductive disorders and sexual dysfunction. In fact, sperm quality has a significant impact on fertilization success and embryo development. The current study aimed to investigate the effect of Borago officinalis L extract on serum testosterone levels, sperm parameters, in the streptozotocin (STZ)-induced mouse model of diabetes.
Materials and Methods: In this research, 30 male mice were randomly divided in 3 groups control, diabetic (Streptozotocin 150 mg/kg) and diabetic + Borago officinalis L (400 mg/kg) groups. After 6 weeks of treatment, the mice were sacrificed and in each group of mice, sperm parameters and testosterone were measured
Results: The results revealed a decrease in body and testis weight and elevated blood FBS levels in the diabetic group, compared to the control. However, Borago treatment significantly increased body and testis weight, while serum FBS levels were decreased, in comparison to the diabetic group. In addition, Borago significantly increased blood testosterone levels, compared to the diabetic group.
Conclusion: The present study showed that, Borago officinalis in male mice has a healing effect on sperm parameters against the damage of diabetes |
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| ISSN: | 1560-652X 2345-4040 |