POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG
Objective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing ‘switch-of latera...
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Istanbul University Press
2021-04-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/0CB6565F6B2946959FE02EC6161498DF |
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| author | Nermin Görkem Şirin İnan Bedia Samancı Ebru Yılmaz Ayşen Zehra Gökyiğit Betül Baykan Rabia Candan Gürses Nerses Bebek |
| author_facet | Nermin Görkem Şirin İnan Bedia Samancı Ebru Yılmaz Ayşen Zehra Gökyiğit Betül Baykan Rabia Candan Gürses Nerses Bebek |
| author_sort | Nermin Görkem Şirin İnan |
| collection | DOAJ |
| description | Objective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing ‘switch-of lateralisation’ (SL) and ‘bilateral asynchrony’ (BA) in ictal scalp EEG and compare their results with patients with TLE and none of these patterns. Methods: Twenty-four patients with TLE showing SL and/or BA in at least one of their seizures in video-EEG monitoring and 38 patients with TLE and without these patterns who had epilepsy surgery and a follow-up at least 5-years were included. The clinical, electrophysiological and imaging features were evaluated and a statistical comparison was performed between the groups. Results: Bilateral hypometabolism was more frequent in patients with SL and/or BA (39%) than in patients without these patterns (0%, p=0.040) in parallel with bilateral interictal epileptiform discharges and bilateral abnormalities in MRI. The presence of unilateral or bilateral hypometabolism was not related to postsurgical outcome in patients with SL and/or BA. Conclusion: The possibility of low accuracy in the lateralisation of hypometabolism in FDG-PET might be interpreted cautiously in TLE with bilateral independent ictal activity like SL and BA. |
| format | Article |
| id | doaj-art-d532ae992dfd48bc9fde34d9a544384d |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-d532ae992dfd48bc9fde34d9a544384d2025-08-20T02:15:33ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-04-0184217518010.26650/IUITFD.2020.0053123456POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEGNermin Görkem Şirin İnan0https://orcid.org/0000-0001-8792-2929Bedia Samancı1https://orcid.org/0000-0003-0667-2329Ebru Yılmaz2https://orcid.org/0000-0002-6025-2248Ayşen Zehra Gökyiğit3https://orcid.org/0000-0003-4914-1712Betül Baykan4https://orcid.org/0000-0002-3360-659XRabia Candan Gürses5https://orcid.org/0000-0002-3752-1825Nerses Bebek6https://orcid.org/0000-0002-4749-1471İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing ‘switch-of lateralisation’ (SL) and ‘bilateral asynchrony’ (BA) in ictal scalp EEG and compare their results with patients with TLE and none of these patterns. Methods: Twenty-four patients with TLE showing SL and/or BA in at least one of their seizures in video-EEG monitoring and 38 patients with TLE and without these patterns who had epilepsy surgery and a follow-up at least 5-years were included. The clinical, electrophysiological and imaging features were evaluated and a statistical comparison was performed between the groups. Results: Bilateral hypometabolism was more frequent in patients with SL and/or BA (39%) than in patients without these patterns (0%, p=0.040) in parallel with bilateral interictal epileptiform discharges and bilateral abnormalities in MRI. The presence of unilateral or bilateral hypometabolism was not related to postsurgical outcome in patients with SL and/or BA. Conclusion: The possibility of low accuracy in the lateralisation of hypometabolism in FDG-PET might be interpreted cautiously in TLE with bilateral independent ictal activity like SL and BA.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/0CB6565F6B2946959FE02EC6161498DFtemporal lobe epilepsyictal propagation patternsswitch-of lateralisationbilateral asynchronyfdg-petfunctional imaging |
| spellingShingle | Nermin Görkem Şirin İnan Bedia Samancı Ebru Yılmaz Ayşen Zehra Gökyiğit Betül Baykan Rabia Candan Gürses Nerses Bebek POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG İstanbul Tıp Fakültesi Dergisi temporal lobe epilepsy ictal propagation patterns switch-of lateralisation bilateral asynchrony fdg-pet functional imaging |
| title | POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG |
| title_full | POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG |
| title_fullStr | POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG |
| title_full_unstemmed | POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG |
| title_short | POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG |
| title_sort | positron emission tomography in patients with drug resistant temporal lobe epilepsy with different ictal propagation patterns in scalp eeg |
| topic | temporal lobe epilepsy ictal propagation patterns switch-of lateralisation bilateral asynchrony fdg-pet functional imaging |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/0CB6565F6B2946959FE02EC6161498DF |
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