Targeting the mTOR pathway in breast cancer
Mechanistic target of rapamycin controls cell growth, metabolism, and aging in response to nutrients, cellular energy stage, and growth factors. In cancers including breast cancer, mechanistic target of rapamycin is frequently upregulated. Blocking mechanistic target of rapamycin with rapamycin, fir...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317710825 |
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| _version_ | 1849700623930359808 |
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| author | Jia Liu Hui-Qing Li Fu-Xia Zhou Jie-Wen Yu Ling Sun Zhong-Hou Han |
| author_facet | Jia Liu Hui-Qing Li Fu-Xia Zhou Jie-Wen Yu Ling Sun Zhong-Hou Han |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | Mechanistic target of rapamycin controls cell growth, metabolism, and aging in response to nutrients, cellular energy stage, and growth factors. In cancers including breast cancer, mechanistic target of rapamycin is frequently upregulated. Blocking mechanistic target of rapamycin with rapamycin, first-generation and second-generation mechanistic target of rapamycin inhibitors, called rapalogs, have shown potent reduction of breast cancer tumor growth in preclinical models and clinical trials. In this review, we summarize the fundamental role of the mechanistic target of rapamycin pathway in driving breast tumors. Moreover, we also review key molecules involved with aberrant mechanistic target of rapamycin pathway activation in breast cancer and current efforts to target these components for therapeutic gain. Further development of predictive biomarkers will be useful in the selection of patients who will benefit from inhibition of the mechanistic target of rapamycin pathway. |
| format | Article |
| id | doaj-art-d5311ec7ed06452eadb8d8548684dffa |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-d5311ec7ed06452eadb8d8548684dffa2025-08-20T03:18:12ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317710825Targeting the mTOR pathway in breast cancerJia LiuHui-Qing LiFu-Xia ZhouJie-Wen YuLing SunZhong-Hou HanMechanistic target of rapamycin controls cell growth, metabolism, and aging in response to nutrients, cellular energy stage, and growth factors. In cancers including breast cancer, mechanistic target of rapamycin is frequently upregulated. Blocking mechanistic target of rapamycin with rapamycin, first-generation and second-generation mechanistic target of rapamycin inhibitors, called rapalogs, have shown potent reduction of breast cancer tumor growth in preclinical models and clinical trials. In this review, we summarize the fundamental role of the mechanistic target of rapamycin pathway in driving breast tumors. Moreover, we also review key molecules involved with aberrant mechanistic target of rapamycin pathway activation in breast cancer and current efforts to target these components for therapeutic gain. Further development of predictive biomarkers will be useful in the selection of patients who will benefit from inhibition of the mechanistic target of rapamycin pathway.https://doi.org/10.1177/1010428317710825 |
| spellingShingle | Jia Liu Hui-Qing Li Fu-Xia Zhou Jie-Wen Yu Ling Sun Zhong-Hou Han Targeting the mTOR pathway in breast cancer Tumor Biology |
| title | Targeting the mTOR pathway in breast cancer |
| title_full | Targeting the mTOR pathway in breast cancer |
| title_fullStr | Targeting the mTOR pathway in breast cancer |
| title_full_unstemmed | Targeting the mTOR pathway in breast cancer |
| title_short | Targeting the mTOR pathway in breast cancer |
| title_sort | targeting the mtor pathway in breast cancer |
| url | https://doi.org/10.1177/1010428317710825 |
| work_keys_str_mv | AT jialiu targetingthemtorpathwayinbreastcancer AT huiqingli targetingthemtorpathwayinbreastcancer AT fuxiazhou targetingthemtorpathwayinbreastcancer AT jiewenyu targetingthemtorpathwayinbreastcancer AT lingsun targetingthemtorpathwayinbreastcancer AT zhonghouhan targetingthemtorpathwayinbreastcancer |