Simultaneous detection of Ca2+ and diacylglycerol signaling in living cells.

Simultaneous detection of Ca2+ and diacylglycerol signaling in living cells.

Phospholipase C produces two second messengers--diacylglycerol (DAG), which remains in the membrane, and inositol triphosphate (IP(3)), which triggers the release of calcium ions (Ca(2+)) from intracellular stores. Genetically encoded sensors based on a single circularly permuted fluorescent protein...

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Bibliographic Details
Main Authors: Paul Tewson, Mara Westenberg, Yongxin Zhao, Robert E Campbell, Anne Marie Quinn, Thomas E Hughes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0042791&type=printable
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