Association and mediation between circulating inflammatory proteins and skin fibrosis

Association and mediation between circulating inflammatory proteins and skin fibrosis

ObjectiveSkin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating inflammatory proteins (CIPs) and skin fibrosis remains unclear. To investigate this potential association and mediated effect, Mendelian randomization (MR) and t...

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Bibliographic Details
Main Authors: Zirui Zhao, Dongming Lv, Ruixi Zeng, Yanchao Rong, Zhongye Xu, Rong Yin, Zhicheng Hu, Xiaoling Cao, Bing Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
circulating inflammatory protein
skin fibrosis
bidirectional Mendelian randomization
mediation analysis
blood metabolite
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1416993/full
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