The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase prot...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6518308 |
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| author | Beata Pucher Magdalena Sobieska Michal Grzegorowski Jaroslaw Szydlowski |
| author_facet | Beata Pucher Magdalena Sobieska Michal Grzegorowski Jaroslaw Szydlowski |
| author_sort | Beata Pucher |
| collection | DOAJ |
| description | The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase proteins (APP), such as C-reactive protein (CRP), alpha-1-antitrypsin (AT), alpha-1-antichymotrypsin (ACT), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), transferrin (Tf), alpha-2-macroglobulin (A2M), and haptoglobin (Hp) were obtained at 3 time points. The glycosylation profiles of AGP, ACT, and Tf were completed. An increased AGP level was observed in girls. The AGP glycosylation revealed the advantage of the W0 variant over the W1 variant. W1 and W2 were decreased in boys. W3 emerged in boys. The Tf concentration and T4 variant were lower compared to the control group. The A2M level was lower after treatment. The Hp and AT levels were decreased a few weeks later. The ACT glycosylation revealed a decrease of the A4 variant in boys. In conclusion, the inflammatory reaction during pseudocroup was of low intensity. The APP glycosylation suggested a chronic process. In a follow-up investigation, no normalization of the parameters was noted, but signs of persistent inflammation were observed. |
| format | Article |
| id | doaj-art-d5291b1f53b04ff1b3c967353814cd68 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d5291b1f53b04ff1b3c967353814cd682025-02-03T01:27:26ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/65183086518308The Acute Phase Proteins Reaction in Children Suffering from PseudocroupBeata Pucher0Magdalena Sobieska1Michal Grzegorowski2Jaroslaw Szydlowski3Department of Pediatric Otolaryngology of Poznan University of Medical Sciences, 60-572 Poznan, Szpitalna 27/33, PolandDepartment of Physiotherapy, Chair for Physiotherapy and Rehabilitation of Poznan University of Medical Sciences, 60-545 Poznan, 28 Czerwca 1956 r. 135/147, PolandDepartment of Pediatric Otolaryngology of Poznan University of Medical Sciences, 60-572 Poznan, Szpitalna 27/33, PolandDepartment of Pediatric Otolaryngology of Poznan University of Medical Sciences, 60-572 Poznan, Szpitalna 27/33, PolandThe aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase proteins (APP), such as C-reactive protein (CRP), alpha-1-antitrypsin (AT), alpha-1-antichymotrypsin (ACT), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), transferrin (Tf), alpha-2-macroglobulin (A2M), and haptoglobin (Hp) were obtained at 3 time points. The glycosylation profiles of AGP, ACT, and Tf were completed. An increased AGP level was observed in girls. The AGP glycosylation revealed the advantage of the W0 variant over the W1 variant. W1 and W2 were decreased in boys. W3 emerged in boys. The Tf concentration and T4 variant were lower compared to the control group. The A2M level was lower after treatment. The Hp and AT levels were decreased a few weeks later. The ACT glycosylation revealed a decrease of the A4 variant in boys. In conclusion, the inflammatory reaction during pseudocroup was of low intensity. The APP glycosylation suggested a chronic process. In a follow-up investigation, no normalization of the parameters was noted, but signs of persistent inflammation were observed.http://dx.doi.org/10.1155/2019/6518308 |
| spellingShingle | Beata Pucher Magdalena Sobieska Michal Grzegorowski Jaroslaw Szydlowski The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup Mediators of Inflammation |
| title | The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup |
| title_full | The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup |
| title_fullStr | The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup |
| title_full_unstemmed | The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup |
| title_short | The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup |
| title_sort | acute phase proteins reaction in children suffering from pseudocroup |
| url | http://dx.doi.org/10.1155/2019/6518308 |
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