Brain anatomy differences in Chinese children who stutter: a preliminary study
Background and purposeIt is unknown the neural mechanisms of developmental stuttering (DS). The aim of this study was to investigate the changes in the structural morphology of the brain in Chinese children who stutter.MethodsA case–control study was conducted to collect magnetic resonance imaging d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1483157/full |
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| author | Dan Ma Dan Ma Lingling Wang Lingling Wang Sai Liu Sai Liu XinMao Ma XinMao Ma Fenglin Jia Fenglin Jia Yimin Hua Yimin Hua Yi Liao Yi Liao Haibo Qu Haibo Qu |
| author_facet | Dan Ma Dan Ma Lingling Wang Lingling Wang Sai Liu Sai Liu XinMao Ma XinMao Ma Fenglin Jia Fenglin Jia Yimin Hua Yimin Hua Yi Liao Yi Liao Haibo Qu Haibo Qu |
| author_sort | Dan Ma |
| collection | DOAJ |
| description | Background and purposeIt is unknown the neural mechanisms of developmental stuttering (DS). The aim of this study was to investigate the changes in the structural morphology of the brain in Chinese children who stutter.MethodsA case–control study was conducted to collect magnetic resonance imaging data from stuttering and non-stuttering children, thereby analyzing whole-brain gray matter volume and cortical morphological changes in stuttering children.ResultsA total of 108 subjects were recruited (stuttering group: control group = 1:1). Comparing to healthy controls, the gray matter volume was significantly decreased in right temporal gyrus and bilateral cerebellum. Additionally, there was a significant reduction in cortical folds in the right insula and right superior temporal gyrus. Moreover, the gray matter volume of the right cerebellum and right temporal gyrus is related to the severity score of stuttering.ConclusionThe present study proposes that the neural mechanisms underlying DS are intricately linked to the cortico-basal ganglia-thalamo-cortical loop and the dorsal language pathway. This finding is expected to provide reference value for the clinical treatment of DS. |
| format | Article |
| id | doaj-art-d5256504d987482d9f80cf22835426ec |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-d5256504d987482d9f80cf22835426ec2025-01-27T05:14:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.14831571483157Brain anatomy differences in Chinese children who stutter: a preliminary studyDan Ma0Dan Ma1Lingling Wang2Lingling Wang3Sai Liu4Sai Liu5XinMao Ma6XinMao Ma7Fenglin Jia8Fenglin Jia9Yimin Hua10Yimin Hua11Yi Liao12Yi Liao13Haibo Qu14Haibo Qu15Department of Rehabilitation Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Rehabilitation Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Second University Hospital, Sichuan University, Chengdu, ChinaBackground and purposeIt is unknown the neural mechanisms of developmental stuttering (DS). The aim of this study was to investigate the changes in the structural morphology of the brain in Chinese children who stutter.MethodsA case–control study was conducted to collect magnetic resonance imaging data from stuttering and non-stuttering children, thereby analyzing whole-brain gray matter volume and cortical morphological changes in stuttering children.ResultsA total of 108 subjects were recruited (stuttering group: control group = 1:1). Comparing to healthy controls, the gray matter volume was significantly decreased in right temporal gyrus and bilateral cerebellum. Additionally, there was a significant reduction in cortical folds in the right insula and right superior temporal gyrus. Moreover, the gray matter volume of the right cerebellum and right temporal gyrus is related to the severity score of stuttering.ConclusionThe present study proposes that the neural mechanisms underlying DS are intricately linked to the cortico-basal ganglia-thalamo-cortical loop and the dorsal language pathway. This finding is expected to provide reference value for the clinical treatment of DS.https://www.frontiersin.org/articles/10.3389/fneur.2025.1483157/fulldevelopmental stutteringgray mattercortical morphologystructural magnetic resonanceChinese children |
| spellingShingle | Dan Ma Dan Ma Lingling Wang Lingling Wang Sai Liu Sai Liu XinMao Ma XinMao Ma Fenglin Jia Fenglin Jia Yimin Hua Yimin Hua Yi Liao Yi Liao Haibo Qu Haibo Qu Brain anatomy differences in Chinese children who stutter: a preliminary study Frontiers in Neurology developmental stuttering gray matter cortical morphology structural magnetic resonance Chinese children |
| title | Brain anatomy differences in Chinese children who stutter: a preliminary study |
| title_full | Brain anatomy differences in Chinese children who stutter: a preliminary study |
| title_fullStr | Brain anatomy differences in Chinese children who stutter: a preliminary study |
| title_full_unstemmed | Brain anatomy differences in Chinese children who stutter: a preliminary study |
| title_short | Brain anatomy differences in Chinese children who stutter: a preliminary study |
| title_sort | brain anatomy differences in chinese children who stutter a preliminary study |
| topic | developmental stuttering gray matter cortical morphology structural magnetic resonance Chinese children |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1483157/full |
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