Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis
Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2011/315134 |
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| author | Jennifer S. Anderson Jennifer A. Nettleton W. Gregory Hundley Michael Y. Tsai Lyn M. Steffen Rozenn N. Lemaitre David Siscovick João Lima Martin R. Prince David Herrington |
| author_facet | Jennifer S. Anderson Jennifer A. Nettleton W. Gregory Hundley Michael Y. Tsai Lyn M. Steffen Rozenn N. Lemaitre David Siscovick João Lima Martin R. Prince David Herrington |
| author_sort | Jennifer S. Anderson |
| collection | DOAJ |
| description | Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β=1.89, P=0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β=0.009, P=0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men. |
| format | Article |
| id | doaj-art-d523aa4f4a7246548be54dee5a9b20ff |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-d523aa4f4a7246548be54dee5a9b20ff2025-02-03T06:13:55ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/315134315134Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of AtherosclerosisJennifer S. Anderson0Jennifer A. Nettleton1W. Gregory Hundley2Michael Y. Tsai3Lyn M. Steffen4Rozenn N. Lemaitre5David Siscovick6João Lima7Martin R. Prince8David Herrington9Division of Cardiology, Deparment of Internal Medicine, Wake Forest University, Winston-Salem, NC 27157, USADivision of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USADivision of Cardiology, Deparment of Internal Medicine, Wake Forest University, Winston-Salem, NC 27157, USADivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USADivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USADepartments of Medicine and Epidemiology, University of Washington, Seattle, WA 98105, USADepartments of Medicine and Epidemiology, University of Washington, Seattle, WA 98105, USADivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 2187-0020, USADepartment of Radiology, Columbia College of Physicians and Surgeons, New York, NY 10032, USADivision of Cardiology, Deparment of Internal Medicine, Wake Forest University, Winston-Salem, NC 27157, USABackground. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β=1.89, P=0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β=0.009, P=0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.http://dx.doi.org/10.1155/2011/315134 |
| spellingShingle | Jennifer S. Anderson Jennifer A. Nettleton W. Gregory Hundley Michael Y. Tsai Lyn M. Steffen Rozenn N. Lemaitre David Siscovick João Lima Martin R. Prince David Herrington Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis Journal of Nutrition and Metabolism |
| title | Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis |
| title_full | Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis |
| title_fullStr | Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis |
| title_full_unstemmed | Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis |
| title_short | Associations of Plasma Phospholipid Omega-6 and Omega-3 Polyunsaturated Fatty Acid Levels and MRI Measures of Cardiovascular Structure and Function: The Multiethnic Study of Atherosclerosis |
| title_sort | associations of plasma phospholipid omega 6 and omega 3 polyunsaturated fatty acid levels and mri measures of cardiovascular structure and function the multiethnic study of atherosclerosis |
| url | http://dx.doi.org/10.1155/2011/315134 |
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