Novel outpatient infusion model of blinatumomab: case studies of two patients
[Objective] To evaluate the feasibility of a novel outpatient infusion model for blinatumomab in two acute lymphoblastic leukemia (ALL) patients, aiming to address challenges of poor treatment tolerance, high healthcare costs, and compromised quality of life, thereby providing clinical insights for...
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| Format: | Article |
| Language: | zho |
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-04-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.015&lang=en |
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| author | LI Guijun JIANG Xuemei WANG Xin XU Qiuxia LI Jianhui DAI Susi HE Ying YI Hai CHEN Dan |
| author_facet | LI Guijun JIANG Xuemei WANG Xin XU Qiuxia LI Jianhui DAI Susi HE Ying YI Hai CHEN Dan |
| author_sort | LI Guijun |
| collection | DOAJ |
| description | [Objective] To evaluate the feasibility of a novel outpatient infusion model for blinatumomab in two acute lymphoblastic leukemia (ALL) patients, aiming to address challenges of poor treatment tolerance, high healthcare costs, and compromised quality of life, thereby providing clinical insights for broader adoption of this approach. [Methods] Two post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients undergoing blinatumomab maintenance therapy were selected to evaluate the efficacy of the outpatient infusion model. Patient selection criteria, nursing protocols, standardized workflows, and advancements in infusion practices were systematically analyzed combined with a review of global developments in this field. [Results] Both patients completed outpatient blinatumomab infusion without severe adverse events, demonstrating preliminary feasibility and safety of this model. The novel approach enhanced treatment convenience, reduced hospitalization costs, and improved quality of life. [Conclusion] Despite the limited sample size, this pilot study highlights the potential of outpatient blinatumomab administration as a viable alternative to traditional inpatient regimens. |
| format | Article |
| id | doaj-art-d521e72c369e4f92a51877d0c547c8f9 |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-d521e72c369e4f92a51877d0c547c8f92025-08-20T02:28:19ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-04-0138455756110.13303/j.cjbt.issn.1004-549x.2025.04.0151004-549X(2025)4-0557-05Novel outpatient infusion model of blinatumomab: case studies of two patientsLI Guijun0JIANG Xuemei1WANG Xin2XU Qiuxia3LI Jianhui4DAI Susi5HE Ying6YI Hai7CHEN Dan8Department of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, ChinaDepartment of Hematology, General Hospital of Western Theater Command of the Chinese People's Liberation Army, Chengdu 610000, China[Objective] To evaluate the feasibility of a novel outpatient infusion model for blinatumomab in two acute lymphoblastic leukemia (ALL) patients, aiming to address challenges of poor treatment tolerance, high healthcare costs, and compromised quality of life, thereby providing clinical insights for broader adoption of this approach. [Methods] Two post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients undergoing blinatumomab maintenance therapy were selected to evaluate the efficacy of the outpatient infusion model. Patient selection criteria, nursing protocols, standardized workflows, and advancements in infusion practices were systematically analyzed combined with a review of global developments in this field. [Results] Both patients completed outpatient blinatumomab infusion without severe adverse events, demonstrating preliminary feasibility and safety of this model. The novel approach enhanced treatment convenience, reduced hospitalization costs, and improved quality of life. [Conclusion] Despite the limited sample size, this pilot study highlights the potential of outpatient blinatumomab administration as a viable alternative to traditional inpatient regimens.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.015&lang=enblinatumomabacute lymphoblastic leukemia (all)outpatient infusion |
| spellingShingle | LI Guijun JIANG Xuemei WANG Xin XU Qiuxia LI Jianhui DAI Susi HE Ying YI Hai CHEN Dan Novel outpatient infusion model of blinatumomab: case studies of two patients Zhongguo shuxue zazhi blinatumomab acute lymphoblastic leukemia (all) outpatient infusion |
| title | Novel outpatient infusion model of blinatumomab: case studies of two patients |
| title_full | Novel outpatient infusion model of blinatumomab: case studies of two patients |
| title_fullStr | Novel outpatient infusion model of blinatumomab: case studies of two patients |
| title_full_unstemmed | Novel outpatient infusion model of blinatumomab: case studies of two patients |
| title_short | Novel outpatient infusion model of blinatumomab: case studies of two patients |
| title_sort | novel outpatient infusion model of blinatumomab case studies of two patients |
| topic | blinatumomab acute lymphoblastic leukemia (all) outpatient infusion |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.015&lang=en |
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