Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex

Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex

Abstract The Pro/N-degron recognizing C-terminal to LisH (CTLH) complex is an E3 ligase of emerging interest in the developmental biology field and for targeted protein degradation (TPD) modalities. The human CTLH complex forms distinct supramolecular ring-shaped structures dependent on the multimer...

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Main Authors: Matthew E. R. Maitland, Gabriel Onea, Dominic D. G. Owens, Brianna C. Gonga-Cavé, Xu Wang, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Gilles A. Lajoie, Caroline Schild-Poulter
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07371-3
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