The combined action of <I>ERG11</I> gene overexpression and its mutations in the development of <I>Candida albicans</I> resistance to triazolic antifungals

The combined action of <I>ERG11</I> gene overexpression and its mutations in the development of <I>Candida albicans</I> resistance to triazolic antifungals

Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles. These mechanisms often operate simultaneously, but the interaction between them remains poorly understood....

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Bibliographic Details
Main Authors: Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2025-07-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
candida albicans
antimycotics
resistance
erg11 gene
overexpression
mutations
Online Access:https://microbiol.crie.ru/jour/article/viewFile/18877/1610
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