Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas
Background: A defective mitotic checkpoint has been proposed to contribute to chromosomal instability (CIN). We have previously shown that expression changes of the mitotic arrest deficiency (MAD) gene family plays a role in renal cell cancer (RCC) characterized by numerical chromosomal changes, nam...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2008-0439 |
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| _version_ | 1850172837458870272 |
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| author | Mafalda Pinto Joana Vieira Franclim R. Ribeiro Maria J. Soares Rui Henrique Jorge Oliveira Carmen Jerónimo Manuel R. Teixeira |
| author_facet | Mafalda Pinto Joana Vieira Franclim R. Ribeiro Maria J. Soares Rui Henrique Jorge Oliveira Carmen Jerónimo Manuel R. Teixeira |
| author_sort | Mafalda Pinto |
| collection | DOAJ |
| description | Background: A defective mitotic checkpoint has been proposed to contribute to chromosomal instability (CIN). We have previously shown that expression changes of the mitotic arrest deficiency (MAD) gene family plays a role in renal cell cancer (RCC) characterized by numerical chromosomal changes, namely papillary and chromophobe carcinomas, but nothing is known about the expression of mitotic checkpoint genes in the clear cell histotype (ccRCC). |
| format | Article |
| id | doaj-art-d51a4f2ae5804b5eb91a1d468cb85062 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-d51a4f2ae5804b5eb91a1d468cb850622025-08-20T02:19:58ZengWileyCellular Oncology1570-58701875-86062008-01-0130538939510.3233/CLO-2008-0439Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney CarcinomasMafalda Pinto0Joana Vieira1Franclim R. Ribeiro2Maria J. Soares3Rui Henrique4Jorge Oliveira5Carmen Jerónimo6Manuel R. Teixeira7Department of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Pathology, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Urology, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalDepartment of Genetics, Portuguese Oncology Institute, 4200-072 Porto, PortugalBackground: A defective mitotic checkpoint has been proposed to contribute to chromosomal instability (CIN). We have previously shown that expression changes of the mitotic arrest deficiency (MAD) gene family plays a role in renal cell cancer (RCC) characterized by numerical chromosomal changes, namely papillary and chromophobe carcinomas, but nothing is known about the expression of mitotic checkpoint genes in the clear cell histotype (ccRCC).http://dx.doi.org/10.3233/CLO-2008-0439 |
| spellingShingle | Mafalda Pinto Joana Vieira Franclim R. Ribeiro Maria J. Soares Rui Henrique Jorge Oliveira Carmen Jerónimo Manuel R. Teixeira Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas Cellular Oncology |
| title | Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas |
| title_full | Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas |
| title_fullStr | Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas |
| title_full_unstemmed | Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas |
| title_short | Overexpression of the Mitotic Checkpoint Genes BUB1 and BUBR1 is Associated with Genomic Complexity in Clear Cell Kidney Carcinomas |
| title_sort | overexpression of the mitotic checkpoint genes bub1 and bubr1 is associated with genomic complexity in clear cell kidney carcinomas |
| url | http://dx.doi.org/10.3233/CLO-2008-0439 |
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