Mass cytometry analysis reveals a cross-tissue immune landscape in Actinobacillus pleuropneumoniae-induced pneumonia

Mass cytometry analysis reveals a cross-tissue immune landscape in Actinobacillus pleuropneumoniae-induced pneumonia

ABSTRACT Porcine contagious pleuropneumonia caused by Actinobacillus pleuropneumoniae (APP) is a fatal respiratory disease that threatens the worldwide farming industry’s health. The immune responses of extrapulmonary tissues play an important role in developing porcine contagious pleuropneumonia; h...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yanyan Tian, Xuan Jiang, Chuntong Bao, Tamin Abdelaal, Dexi Chen, Wenjing Wang, Fengyang Li, Liancheng Lei, Na Li
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-06-01
Series:	Microbiology Spectrum
Subjects:	Actinobacillus pleuropneumoniae immune cell clusters mass cytometry immune response
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02665-24
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Properties of Actinobacillus pleuropneumoniae isolates
by: V. А. Evgrafova, et al.
Published: (2023-06-01)

Immunization of pigs with Actinobacillus pleuropneumonia live attenuated (gene-deleted) vaccine HB04M intramuscularly or intranasally exhibits remarkably rapid protection against heterologous strain challenge
by: Song Qi, et al.
Published: (2025-07-01)

Serotype diversity of Actinobacillus pleuropneumoniae detected by real-time PCR in clinical and subclinical samples from Spanish pig farms during 2017–2022
by: José Luis Arnal Bernal, et al.
Published: (2024-12-01)

Atypical Actinobacillus pleuropneumoniae serotype 12 strains with a higher virulence potential
by: Antony T. Vincent, et al.
Published: (2025-07-01)

Immunogenicity and vaccine efficacy of Actinobacillus pleuropneumoniae-derived extracellular vesicles as a novel vaccine candidate
by: Su Hyun Park, et al.
Published: (2025-12-01)

Post-outbreak dynamics and persistence of Actinobacillus pleuropneumoniae serotype 15 in finisher pigs in Iowa
by: Marcelo Nunes de Almeida, et al.
Published: (2025-05-01)

Serovars and antimicrobial resistance profiles of Actinobacillus pleuropneumoniae isolates from clinical-case pigs in Taiwan
by: Wei-Fan Kwan, et al.
Published: (2025-08-01)

Establishment and application of dual rpa-basic and rpa-lfd detection method for pasteurella multocida and actinobacillus pleuropneumoniae
by: Jingjing LI, et al.
Published: (2024-12-01)

The two-component system CpxAR is required for the high potassium stress survival of Actinobacillus pleuropneumoniae
by: Jiajia Wan, et al.
Published: (2023-09-01)

Correction: The two-component system CpxAR is required for the high potassium stress survival of Actinobacillus pleuropneumoniae
by: Jiajia Wan, et al.
Published: (2025-07-01)

Evaluating the Immunogenic Potential of ApxI and ApxII from <i>Actinobacillus pleuropneumoniae</i>: An Immunoinformatics-Driven Study on mRNA Candidates
by: Yi Deng, et al.
Published: (2025-04-01)

Comparison of the Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and 7 Other Antimicrobial Agents Tested Against Swine Isolates of <i>Actinobacillus pleuropneumoniae</i> and <i>Pasteurella multocida</i>
by: Joseph M. Blondeau, et al.
Published: (2024-11-01)

The Challenge of Developing a Test to Differentiate <i>Actinobacillus pleuropneumoniae</i> Serotypes 9 and 11
by: José Luis Arnal Bernal, et al.
Published: (2025-01-01)

Improved pharmacotherapy after revised dosing regimens of two slow-release formulations of benzylpenicillin in an Actinobacillus pleuropneumoniae infection model in pigs
by: Marie Sjölund, et al.
Published: (2025-04-01)

Biofilm formation in Streptococcus suis: in vitro impact of serovars and assessment of coinfections with other porcine respiratory disease complex bacterial pathogens
by: Rubén Miguélez-Pérez, et al.
Published: (2024-12-01)

Environmental enrichment affects immunity and reduces disease severity in pigs after co-infection, with stronger effects when applied from birth than from weaning
by: Brigitte G. C. de Bruijn, et al.
Published: (2024-12-01)

Pengaruh Fermentasi Actinobacillus sp. pada Kotoran Sapi sebagai Pupuk Terhadap Pertumbuhan Nannochloropsis sp. <br><i>[Fermentation Of Actinobacillus sp. On Cow Dunk As Fertilizer On The Growth Of Nannochloropsis sp. ]<i>
by: Rahayu Kusdarwati, et al.
Published: (2012-04-01)

Health–Economic Impact Attributable to Occurrence of Pleurisy and Pneumonia Lesions in Finishing Pigs
by: Clarisse S. Malcher, et al.
Published: (2024-12-01)

Beyond the Limits: How Is Spectral Flow Cytometry Reshaping the Clinical Landscape and What Is Coming Next?
by: Kamila Czechowska, et al.
Published: (2025-06-01)

Spatial distribution and clustering of contagious caprine pleuropneumonia in goats of Amhara region, Ethiopia
by: Asres Zegeye, et al.
Published: (2024-10-01)

Succinic Acid Production With Actinobacillus succinogenes –Influence of an Electric Potential on the Intercellular NADH/NAD+ Balance
by: Jan‐Niklas Hengsbach, et al.
Published: (2025-01-01)

Modern approaches to the prevention of actinobacillus pleuropneumonia in pigs
by: Nikolay V. Pimenov, et al.
Published: (2025-01-01)

A novel anti-mouse CXCR1 monoclonal antibody, Cx1Mab-8, demonstrates nanomolar affinity in flow cytometry
by: Guanjie Li, et al.
Published: (2025-06-01)

Survey of the approach to the diagnosis and management of bacterial pneumonia in adult horses by equine veterinarians
by: Kate L. Hepworth-Warren, et al.
Published: (2024-12-01)

Implementation of flow cytometry technique for evaluation of neutrophil phagocytic activity in clinical laboratory practice
by: I. G. Shushkova, et al.
Published: (2025-03-01)

A serological survey of wild boar in Serbia for Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae
by: M Ninkovic, et al.
Published: (2024-12-01)

The Power of Reagent Titration in Flow Cytometry
by: Diana L. Bonilla, et al.
Published: (2024-10-01)

Flow cytometry immune profiling of recurrent and newly diagnosed growth hormone secreting pituitary neuroendocrine tumors: comparison of two clinical cases
by: Daria Lisina, et al.
Published: (2025-02-01)

Correction: Atypical Actinobacillus pleuropneumoniae serotype 12 strains with a higher virulence potential
by: Antony T. Vincent, et al.
Published: (2025-07-01)

Neuromorphic imaging cytometry on human blood cells
by: Ziyao Zhang, et al.
Published: (2025-01-01)

Immune monitoring and risk of infection in pediatric liver transplantation: a prospective study
by: Ricardo Cuesta-Martín de la Cámara, et al.
Published: (2025-06-01)

Comparative Genomics of Actinobacillus pleuropneumoniae Serotype 8 Reveals the Importance of Prophages in the Genetic Variability of the Species
by: Isabelle Gonçalves de Oliveira Prado, et al.
Published: (2020-01-01)

Epstein-Barr virus-specific T-cell response in pediatric liver transplant recipients: a cross-sectional study by multiparametric flow cytometry
by: Ricardo Cuesta-Martín de la Cámara, et al.
Published: (2024-10-01)

Monitoring Immune Responses to Vaccination: A Focus on Single-Cell Analysis and Associated Challenges
by: LaToya Montgomery, et al.
Published: (2025-04-01)

A glyco-engineering approach for site-specific conjugation to Fab glycans
by: Maria L. Jaramillo, et al.
Published: (2023-12-01)

DIAGNOSTIC UTILITY OF FLOW CYTOMETRY IN MYELODYSPLASTIC SYNDROMES.
by: Matteo Della Porta, et al.
Published: (2017-02-01)

Study of myelodysplastic features in patients with myelodysplastic syndromes by multicolor flow cytometry
by: O. Yu. Davydova, et al.
Published: (2019-01-01)

CyTOF profiling of bone marrow immune dynamics across myeloma stages
by: Dana Cholujova, et al.
Published: (2025-12-01)

Peripheral blood lymphocyte subsets of Chinese adults with liver steatosis
by: Xiaxiao Yan, et al.
Published: (2025-04-01)

Protocol for phenotyping mouse myeloid and lymphoid cells by mass cytometry
by: Laura Morin, et al.
Published: (2025-03-01)