Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature
Chronic immune sensory polyradiculopathy (CISP) is a rare inflammatory immune disorder affecting the nervous system, primarily targeting the proximal sensory nerve roots. The condition was first described by Sinreich in 2004. We conducted a systematic review of CISP cases published on PubMed to iden...
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| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Neurology International |
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| author | Saurabh Singhal Rahul Khanna Anudeep Surendranath Jayksh Chhabra Vismay Thakkar Rajesh Gupta |
| author_facet | Saurabh Singhal Rahul Khanna Anudeep Surendranath Jayksh Chhabra Vismay Thakkar Rajesh Gupta |
| author_sort | Saurabh Singhal |
| collection | DOAJ |
| description | Chronic immune sensory polyradiculopathy (CISP) is a rare inflammatory immune disorder affecting the nervous system, primarily targeting the proximal sensory nerve roots. The condition was first described by Sinreich in 2004. We conducted a systematic review of CISP cases published on PubMed to identify common clinical presentations, along with neurophysiological, radiological, cerebrospinal fluid (CSF), and other findings. Our review included a total of 22 patients from 8 articles. Many patients presented with gait difficulties and sensory ataxia and were found to have normal nerve conduction studies (NCS) and electromyography (EMG) but exhibited characteristic abnormalities in somatosensory evoked potentials (SSEP), elevated CSF protein levels, thickened nerve roots on contrast-enhanced lumbar spine MRIs, and histological changes on nerve root biopsies. Clinical improvement was observed following treatment with steroids and/or intravenous immunoglobulin (IVIG). The study concluded that while CISP is rare, it is an important clinical entity to consider, as accurate diagnosis and appropriate treatment can lead to significant improvements in neurological symptoms and disabilities. |
| format | Article |
| id | doaj-art-d5153d92f0bb4c5bac4c2cc882342d14 |
| institution | OA Journals |
| issn | 2035-8377 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Neurology International |
| spelling | doaj-art-d5153d92f0bb4c5bac4c2cc882342d142025-08-20T02:01:15ZengMDPI AGNeurology International2035-83772024-10-011661214122210.3390/neurolint16060092Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the LiteratureSaurabh Singhal0Rahul Khanna1Anudeep Surendranath2Jayksh Chhabra3Vismay Thakkar4Rajesh Gupta5Department of Neurology, Well Smart Health Neurology Clinic, Opelousas, LA 70570, USANeurology and Sleep Clinic, PLC, West Burlington, IA 52655, USANeurology, CHI St. Vincent, Hot Springs, AR 71913, USADepartment of Neurology, University of Texas Health Science Center, Houston, TX 77030, USANeurology, Wesley Medical Center, Wichita, KS 67214, USADepartment of Neurology, University of Texas Health Science Center, Houston, TX 77030, USAChronic immune sensory polyradiculopathy (CISP) is a rare inflammatory immune disorder affecting the nervous system, primarily targeting the proximal sensory nerve roots. The condition was first described by Sinreich in 2004. We conducted a systematic review of CISP cases published on PubMed to identify common clinical presentations, along with neurophysiological, radiological, cerebrospinal fluid (CSF), and other findings. Our review included a total of 22 patients from 8 articles. Many patients presented with gait difficulties and sensory ataxia and were found to have normal nerve conduction studies (NCS) and electromyography (EMG) but exhibited characteristic abnormalities in somatosensory evoked potentials (SSEP), elevated CSF protein levels, thickened nerve roots on contrast-enhanced lumbar spine MRIs, and histological changes on nerve root biopsies. Clinical improvement was observed following treatment with steroids and/or intravenous immunoglobulin (IVIG). The study concluded that while CISP is rare, it is an important clinical entity to consider, as accurate diagnosis and appropriate treatment can lead to significant improvements in neurological symptoms and disabilities.https://www.mdpi.com/2035-8377/16/6/92CISPchronic immune sensory polyradiculopathyCIDPAIDPataxiaSSEP |
| spellingShingle | Saurabh Singhal Rahul Khanna Anudeep Surendranath Jayksh Chhabra Vismay Thakkar Rajesh Gupta Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature Neurology International CISP chronic immune sensory polyradiculopathy CIDP AIDP ataxia SSEP |
| title | Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature |
| title_full | Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature |
| title_fullStr | Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature |
| title_full_unstemmed | Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature |
| title_short | Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature |
| title_sort | chronic immune sensory polyradiculopathy cisp a systematic review of the literature |
| topic | CISP chronic immune sensory polyradiculopathy CIDP AIDP ataxia SSEP |
| url | https://www.mdpi.com/2035-8377/16/6/92 |
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