Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs
ABSTRACT Background The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown. Objectives To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy. Animals Two hundred eighty‐five companion dogs with su...
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2025-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70011 |
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| author | Rachel Geiger Joe Mankin Holger A. Volk Steven deDecker Nate vanAsselt Karanbir Randhawa Tara Ehling Charles A. Maitz Ada Naramor Joan R. Coates Catherine Stalin Lauren Johnstone Joanna Morris Ioannis N. Plessas Alexander Forward Laurent Garosi Elena Scarpante Giunio Cherubini Tom Harcourt‐Brown Sheila Carrera‐Justiz Jishnu Rao Gutti Marilia Takada Joel White Koichi Nagata Marc Kent Renee Barber Daisuke Ito Tomohiro Nakayama Ayaka Oshima Naoki Sekigucki Lauren Smith‐Oskrochi Nick Jeffery |
| author_facet | Rachel Geiger Joe Mankin Holger A. Volk Steven deDecker Nate vanAsselt Karanbir Randhawa Tara Ehling Charles A. Maitz Ada Naramor Joan R. Coates Catherine Stalin Lauren Johnstone Joanna Morris Ioannis N. Plessas Alexander Forward Laurent Garosi Elena Scarpante Giunio Cherubini Tom Harcourt‐Brown Sheila Carrera‐Justiz Jishnu Rao Gutti Marilia Takada Joel White Koichi Nagata Marc Kent Renee Barber Daisuke Ito Tomohiro Nakayama Ayaka Oshima Naoki Sekigucki Lauren Smith‐Oskrochi Nick Jeffery |
| author_sort | Rachel Geiger |
| collection | DOAJ |
| description | ABSTRACT Background The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown. Objectives To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy. Animals Two hundred eighty‐five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries. Methods Parallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board‐certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro‐ or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all‐cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival. Results One hundred sixty‐eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99–768) days compared with 696 (IQR: 368–999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357–2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395–564) days after surgery and 673 (95% CI: 565–782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration. Conclusions and Clinical Importance Dogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery. |
| format | Article |
| id | doaj-art-d50c8a8bd2b14e7facf2745494891086 |
| institution | DOAJ |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-d50c8a8bd2b14e7facf27454948910862025-08-20T02:58:00ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-03-01392n/an/a10.1111/jvim.70011Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 DogsRachel Geiger0Joe Mankin1Holger A. Volk2Steven deDecker3Nate vanAsselt4Karanbir Randhawa5Tara Ehling6Charles A. Maitz7Ada Naramor8Joan R. Coates9Catherine Stalin10Lauren Johnstone11Joanna Morris12Ioannis N. Plessas13Alexander Forward14Laurent Garosi15Elena Scarpante16Giunio Cherubini17Tom Harcourt‐Brown18Sheila Carrera‐Justiz19Jishnu Rao Gutti20Marilia Takada21Joel White22Koichi Nagata23Marc Kent24Renee Barber25Daisuke Ito26Tomohiro Nakayama27Ayaka Oshima28Naoki Sekigucki29Lauren Smith‐Oskrochi30Nick Jeffery31Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USADepartment of Clinical Science and Services Royal Veterinary College Hatfield UKDepartment of Clinical Science and Services Royal Veterinary College Hatfield UKDepartment of Surgical Sciences University of Wisconsin Veterinary Care Madison Wisconsin USADepartment of Surgical Sciences University of Wisconsin Veterinary Care Madison Wisconsin USADepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USASmall Animal Clinical Division, School of Biodiversity, One Health and Veterinary Medicine University of Glasgow Glasgow UKSmall Animal Clinical Division, School of Biodiversity, One Health and Veterinary Medicine University of Glasgow Glasgow UKSmall Animal Clinical Division, School of Biodiversity, One Health and Veterinary Medicine University of Glasgow Glasgow UKDavies Veterinary Specialists Hitchin UKDavies Veterinary Specialists Hitchin UKDavies Veterinary Specialists Hitchin UKDWR Veterinary Specialists Cambridgeshire UKDWR Veterinary Specialists Cambridgeshire UKLangford Vets Small Animal Hospital Langford UKCollege of Veterinary Medicine, Department of Small Animal Clinical Sciences University of Florida Gainesville Florida USACollege of Veterinary Medicine, Department of Small Animal Clinical Sciences University of Florida Gainesville Florida USACollege of Veterinary Medicine, Department of Small Animal Clinical Sciences University of Florida Gainesville Florida USADepartment of Small Animal Medicine & Surgery University of Georgia College of Veterinary Medicine Athens Georgia USADepartment of Small Animal Medicine & Surgery University of Georgia College of Veterinary Medicine Athens Georgia USADepartment of Small Animal Medicine & Surgery University of Georgia College of Veterinary Medicine Athens Georgia USADepartment of Small Animal Medicine & Surgery University of Georgia College of Veterinary Medicine Athens Georgia USADepartment of Veterinary Medicine, College of Bioresource Sciences Nihon University Fujisawa JapanDepartment of Veterinary Medicine, College of Bioresource Sciences Nihon University Fujisawa JapanDepartment of Veterinary Medicine, College of Bioresource Sciences Nihon University Fujisawa JapanDepartment of Veterinary Medicine, College of Bioresource Sciences Nihon University Fujisawa JapanDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station Texas USAABSTRACT Background The comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown. Objectives To compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy. Animals Two hundred eighty‐five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries. Methods Parallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board‐certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro‐ or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all‐cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival. Results One hundred sixty‐eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99–768) days compared with 696 (IQR: 368–999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357–2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395–564) days after surgery and 673 (95% CI: 565–782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration. Conclusions and Clinical Importance Dogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery.https://doi.org/10.1111/jvim.70011brain tumorcaninemeningiomaneurologyoncology‐treatment |
| spellingShingle | Rachel Geiger Joe Mankin Holger A. Volk Steven deDecker Nate vanAsselt Karanbir Randhawa Tara Ehling Charles A. Maitz Ada Naramor Joan R. Coates Catherine Stalin Lauren Johnstone Joanna Morris Ioannis N. Plessas Alexander Forward Laurent Garosi Elena Scarpante Giunio Cherubini Tom Harcourt‐Brown Sheila Carrera‐Justiz Jishnu Rao Gutti Marilia Takada Joel White Koichi Nagata Marc Kent Renee Barber Daisuke Ito Tomohiro Nakayama Ayaka Oshima Naoki Sekigucki Lauren Smith‐Oskrochi Nick Jeffery Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs Journal of Veterinary Internal Medicine brain tumor canine meningioma neurology oncology‐treatment |
| title | Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs |
| title_full | Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs |
| title_fullStr | Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs |
| title_full_unstemmed | Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs |
| title_short | Comparison of Survival After Treatment of Presumed Intracranial Meningioma by Radiotherapy or Surgery in 285 Dogs |
| title_sort | comparison of survival after treatment of presumed intracranial meningioma by radiotherapy or surgery in 285 dogs |
| topic | brain tumor canine meningioma neurology oncology‐treatment |
| url | https://doi.org/10.1111/jvim.70011 |
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