ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS
The peripheral blood count of γδТ cells was investigated in patients with new-onset pulmonary tuberculosis depending on the clinical form of the disease, on Mycobacterium tuberculosis susceptibility to antituberculosis drugs, and on the response to intradermal tuberculin administration (Mantoux test...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-03-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/52 |
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| author | E. G. Churina O. I. Urazova V. V. Novitsky T. E. Kononova |
| author_facet | E. G. Churina O. I. Urazova V. V. Novitsky T. E. Kononova |
| author_sort | E. G. Churina |
| collection | DOAJ |
| description | The peripheral blood count of γδТ cells was investigated in patients with new-onset pulmonary tuberculosis depending on the clinical form of the disease, on Mycobacterium tuberculosis susceptibility to antituberculosis drugs, and on the response to intradermal tuberculin administration (Mantoux test). The count of γδТ cells was shown to decrease in all clinical forms of tuberculosis infection; however, the most significant increase in their count was noted in disseminated and fibrocavernous pulmonary tuberculosis, as well as in the presence of multidrug resistance in Mycobacterium tuberculosis (in infiltrative and fibrocavernous forms of the disease) and a negative response to the Mantoux test in patients with infiltrative pulmonary tuberculosis. The demonstrated decrease in the count of circulating γδТ cells in the blood of patients with pulmonary tuberculosis promotes a reduction in the protective immune response to Mycobacterium tuberculosis. |
| format | Article |
| id | doaj-art-d50b55cfc2f44ac89a11155f2bd8e955 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2014-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-d50b55cfc2f44ac89a11155f2bd8e9552025-08-20T02:06:06ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-03-0103596352ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSISE. G. Churina0O. I. Urazova1V. V. Novitsky2T. E. Kononova3Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетThe peripheral blood count of γδТ cells was investigated in patients with new-onset pulmonary tuberculosis depending on the clinical form of the disease, on Mycobacterium tuberculosis susceptibility to antituberculosis drugs, and on the response to intradermal tuberculin administration (Mantoux test). The count of γδТ cells was shown to decrease in all clinical forms of tuberculosis infection; however, the most significant increase in their count was noted in disseminated and fibrocavernous pulmonary tuberculosis, as well as in the presence of multidrug resistance in Mycobacterium tuberculosis (in infiltrative and fibrocavernous forms of the disease) and a negative response to the Mantoux test in patients with infiltrative pulmonary tuberculosis. The demonstrated decrease in the count of circulating γδТ cells in the blood of patients with pulmonary tuberculosis promotes a reduction in the protective immune response to Mycobacterium tuberculosis.https://www.tibl-journal.com/jour/article/view/52pulmonary tuberculosisgamma delta t cellsimmune response |
| spellingShingle | E. G. Churina O. I. Urazova V. V. Novitsky T. E. Kononova ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS Туберкулез и болезни лёгких pulmonary tuberculosis gamma delta t cells immune response |
| title | ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS |
| title_full | ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS |
| title_fullStr | ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS |
| title_full_unstemmed | ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS |
| title_short | ROLE OF GAMMA DELTA T CELLS IN THE IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS |
| title_sort | role of gamma delta t cells in the immune response to mycobacterium tuberculosis |
| topic | pulmonary tuberculosis gamma delta t cells immune response |
| url | https://www.tibl-journal.com/jour/article/view/52 |
| work_keys_str_mv | AT egchurina roleofgammadeltatcellsintheimmuneresponsetomycobacteriumtuberculosis AT oiurazova roleofgammadeltatcellsintheimmuneresponsetomycobacteriumtuberculosis AT vvnovitsky roleofgammadeltatcellsintheimmuneresponsetomycobacteriumtuberculosis AT tekononova roleofgammadeltatcellsintheimmuneresponsetomycobacteriumtuberculosis |