MicroRNAs in Vascular Biology
Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orches...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/794898 |
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| _version_ | 1850172765365075968 |
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| author | Munekazu Yamakuchi |
| author_facet | Munekazu Yamakuchi |
| author_sort | Munekazu Yamakuchi |
| collection | DOAJ |
| description | Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orchestrate a series of pathological events. Despite dramatic improvements in the treatment of atherosclerosis, the molecular basis of vascular inflammation is not well understood. In the last decade, microRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation. Each miRNAs suppresses a set of genes, forming complex regulatory network. This paper provides an overview of current advances that have been made in revealing the roles of miRNAs during vascular inflammation. Recent studies show that miRNAs not only exist inside cells but also circulate in blood. These circulating miRNAs are useful biomarkers for diagnosis of cardiovascular diseases. Furthermore, recent studies demonstrate that circulating miRNAs are delivered into certain recipient cells and act as messengers. These studies suggest that miRNAs provide new therapeutic opportunities. |
| format | Article |
| id | doaj-art-d509e21c73ec419d974006f2dd1f430d |
| institution | OA Journals |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-d509e21c73ec419d974006f2dd1f430d2025-08-20T02:20:00ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/794898794898MicroRNAs in Vascular BiologyMunekazu Yamakuchi0Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box CVRI, Rochester, NY 14642, USAVascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orchestrate a series of pathological events. Despite dramatic improvements in the treatment of atherosclerosis, the molecular basis of vascular inflammation is not well understood. In the last decade, microRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation. Each miRNAs suppresses a set of genes, forming complex regulatory network. This paper provides an overview of current advances that have been made in revealing the roles of miRNAs during vascular inflammation. Recent studies show that miRNAs not only exist inside cells but also circulate in blood. These circulating miRNAs are useful biomarkers for diagnosis of cardiovascular diseases. Furthermore, recent studies demonstrate that circulating miRNAs are delivered into certain recipient cells and act as messengers. These studies suggest that miRNAs provide new therapeutic opportunities.http://dx.doi.org/10.1155/2012/794898 |
| spellingShingle | Munekazu Yamakuchi MicroRNAs in Vascular Biology International Journal of Vascular Medicine |
| title | MicroRNAs in Vascular Biology |
| title_full | MicroRNAs in Vascular Biology |
| title_fullStr | MicroRNAs in Vascular Biology |
| title_full_unstemmed | MicroRNAs in Vascular Biology |
| title_short | MicroRNAs in Vascular Biology |
| title_sort | micrornas in vascular biology |
| url | http://dx.doi.org/10.1155/2012/794898 |
| work_keys_str_mv | AT munekazuyamakuchi micrornasinvascularbiology |