Repurposed Nrf2 activator dimethyl fumarate rescues muscle inflammation and fibrosis in an aggravated mdx mouse model of Duchenne muscular dystrophy

Repurposed Nrf2 activator dimethyl fumarate rescues muscle inflammation and fibrosis in an aggravated mdx mouse model of Duchenne muscular dystrophy

In inherited neuromuscular disease, Duchenne muscular dystrophy (DMD), glucocorticoids significantly slow disease progression yet impart side effects severe enough to preclude use in a significant proportion of patients. Extending our findings that acute treatment with FDA approved multiple sclerosi...

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Bibliographic Details
Main Authors: Stephanie Kourakis, Cara A. Timpani, Ryan M. Bagaric, Bo Qi, Benazir A. Ali, Rebecca Boyer, Guinevere Spiesberger, Nitika Kandhari, Xu Yan, Jujiao Kuang, Ankita Tulangekar, Judy B. de Haan, Deanna Deveson-Lucas, Nicole Stupka, Dirk Fischer, Emma Rybalka
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Duchenne muscular dystrophy
Dimethyl fumarate
Therapeutics
Muscle pathology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001892
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