QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite

QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite

Abstract The repercussions of hormone replacement therapy (HRT) and bisphosphonates pose serious clinical challenges and warrant novel therapies for osteoporosis in menopausal women. To confront this issue, the present research aimed to design and fabricate daidzein (DZ); a phytoestrogen-loaded hydr...

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Bibliographic Details
Main Authors: Namrata Gautam, Debopriya Dutta, Saurabh Mittal, Perwez Alam, Nasr A. Emad, Mohamed H. Al-Sabri, Suraj Pal Verma, Sushama Talegaonkar
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Calcium-phosphate
Hydroxyapatite
Daidzein
Pharmacokinetics
Nanoparticles
Online Access:https://doi.org/10.1038/s41598-025-85463-8
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