Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis

Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis

Abstract Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. Colorectal liver metastasis (CRLM) is a major cause of mortality am...

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Main Authors: Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
CRC
CRLM
Mfsd2a
EMT
S100A14
STAT3
Online Access:https://doi.org/10.1186/s12967-024-05994-y
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