Preferential transmission of minority and drug-resistant clones in polyclonal infections in Mali

Preferential transmission of minority and drug-resistant clones in polyclonal infections in Mali

Abstract Background In polyclonal human malaria infections, the roles of individual clones in human-to-mosquito transmission and their relative transmissibility remain poorly understood. In addition, mutations conferring drug resistance can result in a transmission advantage or disadvantage. Methods...

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Main Authors: Leen N. Vanheer, Emilia Manko, Almahamoudou Mahamar, Jody Phelan, Koualy Sanogo, Youssouf Sinaba, Sidi M. Niambele, Adama Sacko, Sekouba Keita, Ahamadou Youssouf, Makonon Diallo, Harouna M. Soumare, Kjerstin Lanke, Djibrilla Issiaka, Halimatou Diawara, Sekou F. Traore, Lynn Grignard, Alassane Dicko, Chris Drakeley, Susana Campino, William Stone
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Gametocytes
Transmission
Comparative genomics
Genetic diversity
Online Access:https://doi.org/10.1186/s12936-025-05298-6
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