HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil
Persistent oncogenic HPV infection is strongly associated with cervical cancer. Studies have suggested a higher prevalence of HPV in women living with HTLV-1. This study aimed to determine whether HTLV-1 infection is associated with cervicovaginal HPV infection and to characterize HPV types accordin...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/1999-4915/17/2/140 |
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| author | Alisson de Aquino Firmino Paulo Roberto Tavares Gomes Filho Juliana Domett Siqueira Luana Leandro Gois Giselle Calasans de Souza Costa Adenilda Lima Lopes Martins Mariana Lima Drumond Marcelo Alves Soares Bernardo Galvão-Castro Carlos Gustavo Régis da Silva Maria Fernanda Rios Grassi |
| author_facet | Alisson de Aquino Firmino Paulo Roberto Tavares Gomes Filho Juliana Domett Siqueira Luana Leandro Gois Giselle Calasans de Souza Costa Adenilda Lima Lopes Martins Mariana Lima Drumond Marcelo Alves Soares Bernardo Galvão-Castro Carlos Gustavo Régis da Silva Maria Fernanda Rios Grassi |
| author_sort | Alisson de Aquino Firmino |
| collection | DOAJ |
| description | Persistent oncogenic HPV infection is strongly associated with cervical cancer. Studies have suggested a higher prevalence of HPV in women living with HTLV-1. This study aimed to determine whether HTLV-1 infection is associated with cervicovaginal HPV infection and to characterize HPV types according to oncogenic risk. Vaginal fluid samples were subjected to HPV diagnosis via PCR, and positive samples were subjected to Sanger sequencing and massive sequencing. Papanicolaou smears were examined using light microscopy to identify cell abnormalities. Among the 155 women screened, 79 were HTLV-1-infected and 76 were uninfected. HPV PCR identified 23 positive samples (15/79 vs. 8/76; <i>p</i> = 0.13). Twenty-three HPV types were identified, of which only types 31, 54, and 58 were present in both groups. When the number of HPV58 infections in each group was compared, women with HTLV-1 had a higher prevalence (8/79 versus 1/76; <i>p</i> = 0.03). In total, 61.9% of HTLV-1-infected women had at least one high-risk or probable high-risk HPV type (<i>p</i> = 0.12). Cytopathological findings were not significantly different between the groups. Further research is needed to determine whether HTLV-1 infection affects HPV progression and cervical cancer development and to assess the potential benefits of vaccination for women living with HTLV-1. |
| format | Article |
| id | doaj-art-d4fffeb4d93a472c9040c6d3b6afa4ed |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-d4fffeb4d93a472c9040c6d3b6afa4ed2025-08-20T03:12:07ZengMDPI AGViruses1999-49152025-01-0117214010.3390/v17020140HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, BrazilAlisson de Aquino Firmino0Paulo Roberto Tavares Gomes Filho1Juliana Domett Siqueira2Luana Leandro Gois3Giselle Calasans de Souza Costa4Adenilda Lima Lopes Martins5Mariana Lima Drumond6Marcelo Alves Soares7Bernardo Galvão-Castro8Carlos Gustavo Régis da Silva9Maria Fernanda Rios Grassi10Centro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilCentro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilCentro de Pesquisa (CPQ), Instituto Nacional de Câncer (INCA), Rio de Janeiro 20231-050, RJ, BrazilLaboratório Avançado de Saúde Pública (LASP), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador 40296-710, BA, BrazilInstituto de Ciências da Saúde (ICS), Universidade Federal da Bahia (UFBA), Salvador 40110-902, BA, BrazilCentro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilCentro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilCentro de Pesquisa (CPQ), Instituto Nacional de Câncer (INCA), Rio de Janeiro 20231-050, RJ, BrazilCentro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilLaboratório Avançado de Saúde Pública (LASP), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador 40296-710, BA, BrazilCentro de Atendimento ao Portador de HTLV (CHTLV), Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador 40290-000, BA, BrazilPersistent oncogenic HPV infection is strongly associated with cervical cancer. Studies have suggested a higher prevalence of HPV in women living with HTLV-1. This study aimed to determine whether HTLV-1 infection is associated with cervicovaginal HPV infection and to characterize HPV types according to oncogenic risk. Vaginal fluid samples were subjected to HPV diagnosis via PCR, and positive samples were subjected to Sanger sequencing and massive sequencing. Papanicolaou smears were examined using light microscopy to identify cell abnormalities. Among the 155 women screened, 79 were HTLV-1-infected and 76 were uninfected. HPV PCR identified 23 positive samples (15/79 vs. 8/76; <i>p</i> = 0.13). Twenty-three HPV types were identified, of which only types 31, 54, and 58 were present in both groups. When the number of HPV58 infections in each group was compared, women with HTLV-1 had a higher prevalence (8/79 versus 1/76; <i>p</i> = 0.03). In total, 61.9% of HTLV-1-infected women had at least one high-risk or probable high-risk HPV type (<i>p</i> = 0.12). Cytopathological findings were not significantly different between the groups. Further research is needed to determine whether HTLV-1 infection affects HPV progression and cervical cancer development and to assess the potential benefits of vaccination for women living with HTLV-1.https://www.mdpi.com/1999-4915/17/2/140HTLV-1HPVcervical cancer |
| spellingShingle | Alisson de Aquino Firmino Paulo Roberto Tavares Gomes Filho Juliana Domett Siqueira Luana Leandro Gois Giselle Calasans de Souza Costa Adenilda Lima Lopes Martins Mariana Lima Drumond Marcelo Alves Soares Bernardo Galvão-Castro Carlos Gustavo Régis da Silva Maria Fernanda Rios Grassi HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil Viruses HTLV-1 HPV cervical cancer |
| title | HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil |
| title_full | HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil |
| title_fullStr | HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil |
| title_full_unstemmed | HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil |
| title_short | HTLV-1 Infection and Cervicovaginal Susceptibility to High-Risk HPV: Findings from Women Living with HTLV-1 in Salvador, Brazil |
| title_sort | htlv 1 infection and cervicovaginal susceptibility to high risk hpv findings from women living with htlv 1 in salvador brazil |
| topic | HTLV-1 HPV cervical cancer |
| url | https://www.mdpi.com/1999-4915/17/2/140 |
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