The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a

Abstract Trimethylamine oxide (TMAO) is a newly found intestinal microbiota metabolite. Here, we aimed to explore the effects of TMAO on calcium homeostasis and its implication in cardiac hypertrophy, especially focusing on the regulatory mechanism of TMAO on the key calcium transporter SERCA2a. Ech...

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Main Authors: Dongyu Lei, Yi Liu, Yuan Liu, Yujie Jiang, Yuyan Lei, Feilong Zhao, Wenqun Li, Zhonghua Ouyang, Lulu Chen, Siyuan Tang, Dongsheng Ouyang, Xiaohui Li, Ying Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08016-9
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