A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features.
<h4>Purpose</h4>We proposed a novel morphological classification for intraductal papillary neoplasm of the bile duct (IPNB) and evaluated its association with postoperative prognosis.<h4>Methods</h4>Forty-two IPNB patients who underwent surgical resection were classified morp...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0325081 |
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| author | Daisuke Noguchi Naohisa Kuriyama Yuji Kozuka Haruna Komatubara Tatsuya Sakamoto Takahiro Ito Aoi Hayasaki Yusuke Iizawa Takehiro Fujii Akihiro Tanemura Yasuhiro Murata Masashi Kishiwada Shugo Mizuno |
| author_facet | Daisuke Noguchi Naohisa Kuriyama Yuji Kozuka Haruna Komatubara Tatsuya Sakamoto Takahiro Ito Aoi Hayasaki Yusuke Iizawa Takehiro Fujii Akihiro Tanemura Yasuhiro Murata Masashi Kishiwada Shugo Mizuno |
| author_sort | Daisuke Noguchi |
| collection | DOAJ |
| description | <h4>Purpose</h4>We proposed a novel morphological classification for intraductal papillary neoplasm of the bile duct (IPNB) and evaluated its association with postoperative prognosis.<h4>Methods</h4>Forty-two IPNB patients who underwent surgical resection were classified morphologically into three types-branched (n = 10), main duct (n = 26), and mixed (n = 6)-based on preoperative imaging features indicating cystic and/or bile duct involvement. Among them, 32 patients with evaluable specimens were further categorized pathologically into Type 1 (n = 10) and Type 2 (n = 22). Patient characteristics and postoperative outcomes were analyzed.<h4>Results</h4>Intraepithelial neoplasia was more frequently observed in the branched type, whereas invasive carcinoma predominated in the main duct type. In the mixed type, a half of patients involved both intra- and extrahepatic bile ducts, and this type also showed the highest incidence of residual tumor. The mixed type had the poorest 5-year postoperative survival rate (50%), compared to 90% in the main duct type and 100% in the branched type. It also exhibited the highest 5-year recurrence rate (62%). Among IPNB patients with associated invasive carcinoma, tumor infiltration beyond the bile duct wall (p < 0.001) and lymph node metastasis (p = 0.021) were significantly associated with poor prognosis, whereas the anatomical extent of the lesion (intrahepatic, extrahepatic, or both) was not. Morphological classification was significantly correlated with pathological subtypes: the branched type was predominant in Type 1 (60%), while the main duct type predominated in Type 2 (64%) (p = 0.039).<h4>Conclusions</h4>Our novel morphological classification of IPNB correlates with postoperative prognosis and may assist in preoperative planning of surgical strategies for IPNB patients. |
| format | Article |
| id | doaj-art-d4f96d3d08e949d394c372c5a707997f |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-d4f96d3d08e949d394c372c5a707997f2025-08-20T03:25:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e032508110.1371/journal.pone.0325081A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features.Daisuke NoguchiNaohisa KuriyamaYuji KozukaHaruna KomatubaraTatsuya SakamotoTakahiro ItoAoi HayasakiYusuke IizawaTakehiro FujiiAkihiro TanemuraYasuhiro MurataMasashi KishiwadaShugo Mizuno<h4>Purpose</h4>We proposed a novel morphological classification for intraductal papillary neoplasm of the bile duct (IPNB) and evaluated its association with postoperative prognosis.<h4>Methods</h4>Forty-two IPNB patients who underwent surgical resection were classified morphologically into three types-branched (n = 10), main duct (n = 26), and mixed (n = 6)-based on preoperative imaging features indicating cystic and/or bile duct involvement. Among them, 32 patients with evaluable specimens were further categorized pathologically into Type 1 (n = 10) and Type 2 (n = 22). Patient characteristics and postoperative outcomes were analyzed.<h4>Results</h4>Intraepithelial neoplasia was more frequently observed in the branched type, whereas invasive carcinoma predominated in the main duct type. In the mixed type, a half of patients involved both intra- and extrahepatic bile ducts, and this type also showed the highest incidence of residual tumor. The mixed type had the poorest 5-year postoperative survival rate (50%), compared to 90% in the main duct type and 100% in the branched type. It also exhibited the highest 5-year recurrence rate (62%). Among IPNB patients with associated invasive carcinoma, tumor infiltration beyond the bile duct wall (p < 0.001) and lymph node metastasis (p = 0.021) were significantly associated with poor prognosis, whereas the anatomical extent of the lesion (intrahepatic, extrahepatic, or both) was not. Morphological classification was significantly correlated with pathological subtypes: the branched type was predominant in Type 1 (60%), while the main duct type predominated in Type 2 (64%) (p = 0.039).<h4>Conclusions</h4>Our novel morphological classification of IPNB correlates with postoperative prognosis and may assist in preoperative planning of surgical strategies for IPNB patients.https://doi.org/10.1371/journal.pone.0325081 |
| spellingShingle | Daisuke Noguchi Naohisa Kuriyama Yuji Kozuka Haruna Komatubara Tatsuya Sakamoto Takahiro Ito Aoi Hayasaki Yusuke Iizawa Takehiro Fujii Akihiro Tanemura Yasuhiro Murata Masashi Kishiwada Shugo Mizuno A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. PLoS ONE |
| title | A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. |
| title_full | A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. |
| title_fullStr | A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. |
| title_full_unstemmed | A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. |
| title_short | A recent update on the morphological classification of intraductal papillary neoplasm of the bile duct: Correlation with postoperative prognosis and pathological features. |
| title_sort | recent update on the morphological classification of intraductal papillary neoplasm of the bile duct correlation with postoperative prognosis and pathological features |
| url | https://doi.org/10.1371/journal.pone.0325081 |
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