Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction
Introduction: N-heterocyclic carbenes (NHCs) are considered important preferred auxiliary ligands for transition metals due to their strong σ-donor and weak π-acceptor properties and ease of structural modification in catalyst design. The functionalization of NHC by adding different substituent grou...
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2024-05-01
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| author | İrem Bayar Senem Akkoc |
| author_facet | İrem Bayar Senem Akkoc |
| author_sort | İrem Bayar |
| collection | DOAJ |
| description | Introduction: N-heterocyclic carbenes (NHCs) are considered important preferred auxiliary ligands for transition metals due to their strong σ-donor and weak π-acceptor properties and ease of structural modification in catalyst design. The functionalization of NHC by adding different substituent groups is an effective strategy for designing complexes with desired electronic and steric properties. NHC–Pd complexes are of particular importance due to their resistance to air, moisture and heat and their strong stability under catalytic and biological conditions. It is known that NHC–Pd complexes show excellent performance in the Suzuki–Miyaura cross-coupling reaction. The traditional Suzuki–Miyaura reaction involves the cross-coupling reaction of alkyl and arylboronic acids with aryl halides. This reaction has some advantages over other C-C coupling reactions. The use of water as a suitable and reliable solvent in the reaction, the fact that the reaction products are generally poorly soluble in water and can be easily separated from the reaction mixture, the use of non-toxic chemicals, the moderation of reaction conditions, and good functional group compatibility make it useful and worth studying. There are many examples of studies on the application of NHC–Pd complexes in the Suzuki–Miyaura reaction in aqueous media, and the highly effective catalytic activities and versatility of these reactions have been proven. Methods: In this study, a series of benzimidazole-based Pd–NHC complexes were synthesized. The synthesized complexes were characterized by spectroscopic methods. All complexes were tested as catalysts in the Suzuki–Miyaura cross-coupling reaction. Results: According to the obtained results, the synthesized benzimidazole-based Pd–NHC complexes were found to have high catalytic activity in the Suzuki–Miyaura cross-coupling reaction. Conclusions: The synthesized NHC-Pd complexes can be used as potential catalysts due to their high catalytic activity. It is thought that these catalysts can be used in different biochemical studies in the future. |
| format | Article |
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| institution | Kabale University |
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| publishDate | 2024-05-01 |
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| spelling | doaj-art-d4f309ed14c54f12b95f8f782e1fa1762025-08-20T03:44:00ZengMDPI AGProceedings2504-39002024-05-011051710.3390/proceedings2024105007Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reactionİrem Bayar0Senem Akkoc1Faculty of Veterinary, Selçuk University, 42130 Konya, TurkeyFaculty of Pharmacy, Süleyman Demirel University, 32260 Isparta, TurkeyIntroduction: N-heterocyclic carbenes (NHCs) are considered important preferred auxiliary ligands for transition metals due to their strong σ-donor and weak π-acceptor properties and ease of structural modification in catalyst design. The functionalization of NHC by adding different substituent groups is an effective strategy for designing complexes with desired electronic and steric properties. NHC–Pd complexes are of particular importance due to their resistance to air, moisture and heat and their strong stability under catalytic and biological conditions. It is known that NHC–Pd complexes show excellent performance in the Suzuki–Miyaura cross-coupling reaction. The traditional Suzuki–Miyaura reaction involves the cross-coupling reaction of alkyl and arylboronic acids with aryl halides. This reaction has some advantages over other C-C coupling reactions. The use of water as a suitable and reliable solvent in the reaction, the fact that the reaction products are generally poorly soluble in water and can be easily separated from the reaction mixture, the use of non-toxic chemicals, the moderation of reaction conditions, and good functional group compatibility make it useful and worth studying. There are many examples of studies on the application of NHC–Pd complexes in the Suzuki–Miyaura reaction in aqueous media, and the highly effective catalytic activities and versatility of these reactions have been proven. Methods: In this study, a series of benzimidazole-based Pd–NHC complexes were synthesized. The synthesized complexes were characterized by spectroscopic methods. All complexes were tested as catalysts in the Suzuki–Miyaura cross-coupling reaction. Results: According to the obtained results, the synthesized benzimidazole-based Pd–NHC complexes were found to have high catalytic activity in the Suzuki–Miyaura cross-coupling reaction. Conclusions: The synthesized NHC-Pd complexes can be used as potential catalysts due to their high catalytic activity. It is thought that these catalysts can be used in different biochemical studies in the future.https://www.mdpi.com/2504-3900/105/1/7catalystmetal complexesN-heterocyclic carbenesSuzuki-Miyaura |
| spellingShingle | İrem Bayar Senem Akkoc Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction Proceedings catalyst metal complexes N-heterocyclic carbenes Suzuki-Miyaura |
| title | Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction |
| title_full | Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction |
| title_fullStr | Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction |
| title_full_unstemmed | Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction |
| title_short | Catalysis of NHC–Pd Complexes in the Suzuki–Miyaura Cross-Coupling Reaction |
| title_sort | catalysis of nhc pd complexes in the suzuki miyaura cross coupling reaction |
| topic | catalyst metal complexes N-heterocyclic carbenes Suzuki-Miyaura |
| url | https://www.mdpi.com/2504-3900/105/1/7 |
| work_keys_str_mv | AT irembayar catalysisofnhcpdcomplexesinthesuzukimiyauracrosscouplingreaction AT senemakkoc catalysisofnhcpdcomplexesinthesuzukimiyauracrosscouplingreaction |