Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization
Abstract Background Sporadic vestibular schwannoma, a benign tumor affecting the vestibulocochlear nerve, poses significant health challenges due to its impact on hearing, balance, and facial nerve function. Despite known associations with genetic mutations and environmental factors, the causality b...
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2024-12-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01644-3 |
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| author | Yuyang Liu Hui Feng Hengchao Ma Jing Li Yang Yu Hua Zhao Xiaoguang Wang Yun Li Jun Zhang Qi Liu |
| author_facet | Yuyang Liu Hui Feng Hengchao Ma Jing Li Yang Yu Hua Zhao Xiaoguang Wang Yun Li Jun Zhang Qi Liu |
| author_sort | Yuyang Liu |
| collection | DOAJ |
| description | Abstract Background Sporadic vestibular schwannoma, a benign tumor affecting the vestibulocochlear nerve, poses significant health challenges due to its impact on hearing, balance, and facial nerve function. Despite known associations with genetic mutations and environmental factors, the causality between potential risk factors and sporadic vestibular schwannoma remains underexplored. Objective This study aims to investigate the causal effects of various genetically predicted risk factors on sporadic vestibular schwannoma utilizing a Two-Sample Mendelian Randomization (MR) approach to enhance understanding of its etiology and inform prevention strategies. Methods Leveraging data from genome-wide association studies (GWAS), we analyzed 29 risk factors across five categories: related diseases, lifestyle habits, nutritional status, learning ability, and laboratory indicators. The MR analysis employed instrumental variables (IVs) derived from single nucleotide polymorphisms (SNPs) to assess causal relationships, overcoming traditional observational study limitations. Results Our findings highlight significant associations between sporadic vestibular schwannoma and factors such as ovarian cancer, uterine fibroids and lifestyle habits including dietary intake and alcohol consumption. Notably, higher educational attainment and specific laboratory indicators like high-density lipoprotein (HDL) cholesterol levels were linked to altered disease risk. These results suggest a multifaceted etiology involving hormonal, cardiovascular, gastrointestinal, immune, and metabolic pathways. Conclusion This comprehensive MR study provides novel insights into the diverse risk factors contributing to sporadic vestibular schwannoma, emphasizing the role of genetic predispositions, hormonal influences, and lifestyle choices in its development. The associations identified underscore the need for a multidisciplinary research approach and targeted public health strategies to mitigate sporadic vestibular schwannoma risk. Further research into the underlying mechanisms of these associations is crucial for developing effective interventions and improving patient outcomes. |
| format | Article |
| id | doaj-art-d4f1dedb93a14899baae75ea862bd616 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-d4f1dedb93a14899baae75ea862bd6162025-08-20T02:20:47ZengSpringerDiscover Oncology2730-60112024-12-0115111410.1007/s12672-024-01644-3Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian RandomizationYuyang Liu0Hui Feng1Hengchao Ma2Jing Li3Yang Yu4Hua Zhao5Xiaoguang Wang6Yun Li7Jun Zhang8Qi Liu9Department of Neurosurgery, 920th Hospital of Joint Logistics Support ForceDepartment of Zhantansi Outpatient, Jingzhong Medical District of Chinese People’s Liberation Army General HospitalMedical School of Chinese People’s Liberation ArmyDepartment of Neurosurgery, 920th Hospital of Joint Logistics Support ForceDepartment of Zhantansi Outpatient, Jingzhong Medical District of Chinese People’s Liberation Army General HospitalDepartment of Zhantansi Outpatient, Jingzhong Medical District of Chinese People’s Liberation Army General HospitalDepartment of Zhantansi Outpatient, Jingzhong Medical District of Chinese People’s Liberation Army General HospitalDepartment of Zhantansi Outpatient, Jingzhong Medical District of Chinese People’s Liberation Army General HospitalDepartment of Neurosurgery, Chinese People’s Liberation Army General HospitalMedical School of Chinese People’s Liberation ArmyAbstract Background Sporadic vestibular schwannoma, a benign tumor affecting the vestibulocochlear nerve, poses significant health challenges due to its impact on hearing, balance, and facial nerve function. Despite known associations with genetic mutations and environmental factors, the causality between potential risk factors and sporadic vestibular schwannoma remains underexplored. Objective This study aims to investigate the causal effects of various genetically predicted risk factors on sporadic vestibular schwannoma utilizing a Two-Sample Mendelian Randomization (MR) approach to enhance understanding of its etiology and inform prevention strategies. Methods Leveraging data from genome-wide association studies (GWAS), we analyzed 29 risk factors across five categories: related diseases, lifestyle habits, nutritional status, learning ability, and laboratory indicators. The MR analysis employed instrumental variables (IVs) derived from single nucleotide polymorphisms (SNPs) to assess causal relationships, overcoming traditional observational study limitations. Results Our findings highlight significant associations between sporadic vestibular schwannoma and factors such as ovarian cancer, uterine fibroids and lifestyle habits including dietary intake and alcohol consumption. Notably, higher educational attainment and specific laboratory indicators like high-density lipoprotein (HDL) cholesterol levels were linked to altered disease risk. These results suggest a multifaceted etiology involving hormonal, cardiovascular, gastrointestinal, immune, and metabolic pathways. Conclusion This comprehensive MR study provides novel insights into the diverse risk factors contributing to sporadic vestibular schwannoma, emphasizing the role of genetic predispositions, hormonal influences, and lifestyle choices in its development. The associations identified underscore the need for a multidisciplinary research approach and targeted public health strategies to mitigate sporadic vestibular schwannoma risk. Further research into the underlying mechanisms of these associations is crucial for developing effective interventions and improving patient outcomes.https://doi.org/10.1007/s12672-024-01644-3Vestibular schwannomaMendelian RandomizationGenetic risk factorsGenome-wide association studiesEpidemiology |
| spellingShingle | Yuyang Liu Hui Feng Hengchao Ma Jing Li Yang Yu Hua Zhao Xiaoguang Wang Yun Li Jun Zhang Qi Liu Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization Discover Oncology Vestibular schwannoma Mendelian Randomization Genetic risk factors Genome-wide association studies Epidemiology |
| title | Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization |
| title_full | Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization |
| title_fullStr | Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization |
| title_full_unstemmed | Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization |
| title_short | Deciphering the causal landscape: genetic insights into sporadic vestibular schwannoma risk factors through Mendelian Randomization |
| title_sort | deciphering the causal landscape genetic insights into sporadic vestibular schwannoma risk factors through mendelian randomization |
| topic | Vestibular schwannoma Mendelian Randomization Genetic risk factors Genome-wide association studies Epidemiology |
| url | https://doi.org/10.1007/s12672-024-01644-3 |
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