Iron metabolism disorder and artesunate inhibiting tumor growth by inducing ferroptosis in Lymphangioleiomyomatosis

Iron metabolism disorder and artesunate inhibiting tumor growth by inducing ferroptosis in Lymphangioleiomyomatosis

Abstract Background Sirolimus, the therapy choice for lymphangioleiomyomatosis (LAM), displayed cytostatic but not cytocidal action, with disease recurrence after withdrawal. The aim of this study is to identify novel potential biomarkers and therapeutic strategies for LAM patients. Methods TMT-labe...

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Bibliographic Details
Main Authors: Wenxue Bai, Shengding Zhang, Lijuan Hua, Dongyuan Wang, Mengyao Guo, Xuezhao Wang, Ying Zhou, Yong Cao, Qi Wang, Ni Zhang, Bin Xue, Min Xie
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
LAM
Iron metabolism
TRF
Ferroptosis
ART
Online Access:https://doi.org/10.1186/s12931-025-03285-8
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