Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.
Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease b...
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001358&type=printable |
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| author | Sebastien Antoni Tomoka Nakamura Adam L Cohen Jason M Mwenda Goitom Weldegebriel Joseph N M Biey Keith Shaba Gloria Rey-Benito Lucia Helena de Oliveira Maria Tereza da Costa Oliveira Claudia Ortiz Amany Ghoniem Kamal Fahmy Hossam A Ashmony Dovile Videbaek Danni Daniels Roberta Pastore Simarjit Singh Emmanuel Tondo Jayantha B L Liyanage Mohammed Sharifuzzaman Varja Grabovac Nyambat Batmunkh Josephine Logronio George Armah Francis E Dennis Mapaseka Seheri Nonkululeko Magagula Jeffrey Mphahlele Jose Paulo G Leite Irene T Araujo Tulio M Fumian Hanan El Mohammady Galina Semeiko Elena Samoilovich Sidhartha Giri Gagandeep Kang Sarah Thomas Julie Bines Carl D Kirkwood Na Liu Deog-Yong Lee Mirren Iturriza-Gomara Nicola Anne Page Mathew D Esona M Leanne Ward Courtnee N Wright Slavica Mijatovic-Rustempasic Jacqueline E Tate Umesh D Parashar Jon Gentsch Michael D Bowen Fatima Serhan |
| author_facet | Sebastien Antoni Tomoka Nakamura Adam L Cohen Jason M Mwenda Goitom Weldegebriel Joseph N M Biey Keith Shaba Gloria Rey-Benito Lucia Helena de Oliveira Maria Tereza da Costa Oliveira Claudia Ortiz Amany Ghoniem Kamal Fahmy Hossam A Ashmony Dovile Videbaek Danni Daniels Roberta Pastore Simarjit Singh Emmanuel Tondo Jayantha B L Liyanage Mohammed Sharifuzzaman Varja Grabovac Nyambat Batmunkh Josephine Logronio George Armah Francis E Dennis Mapaseka Seheri Nonkululeko Magagula Jeffrey Mphahlele Jose Paulo G Leite Irene T Araujo Tulio M Fumian Hanan El Mohammady Galina Semeiko Elena Samoilovich Sidhartha Giri Gagandeep Kang Sarah Thomas Julie Bines Carl D Kirkwood Na Liu Deog-Yong Lee Mirren Iturriza-Gomara Nicola Anne Page Mathew D Esona M Leanne Ward Courtnee N Wright Slavica Mijatovic-Rustempasic Jacqueline E Tate Umesh D Parashar Jon Gentsch Michael D Bowen Fatima Serhan |
| author_sort | Sebastien Antoni |
| collection | DOAJ |
| description | Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease burden but may also be changing the rotavirus genetic landscape and driving the emergence of new genotypes. We report genotype data of more than 16,000 rotavirus isolates from 40 countries participating in the Global Rotavirus Surveillance Network. Data from a convenience sample of children under five years of age hospitalized with acute watery diarrhea who tested positive for rotavirus were included. Country results were weighted by their estimated rotavirus disease burden to estimate regional genotype distributions. Globally, the most frequent genotypes identified after weighting were G1P[8] (31%), G1P[6] (8%) and G3P[8] (8%). Genotypes varied across WHO Regions and between countries that had and had not introduced rotavirus vaccine. G1P[8] was less frequent among African (36 vs 20%) and European (33 vs 8%) countries that had introduced rotavirus vaccines as compared to countries that had not introduced. Our results describe differences in the distribution of the most common rotavirus genotypes in children with diarrhea in low- and middle-income countries. G1P[8] was less frequent in countries that had introduced the rotavirus vaccine while different strains are emerging or re-emerging in different regions. |
| format | Article |
| id | doaj-art-d4ef36ccc32046b289ac201679a8b81c |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-d4ef36ccc32046b289ac201679a8b81c2025-08-20T03:25:38ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752023-01-01311e000135810.1371/journal.pgph.0001358Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.Sebastien AntoniTomoka NakamuraAdam L CohenJason M MwendaGoitom WeldegebrielJoseph N M BieyKeith ShabaGloria Rey-BenitoLucia Helena de OliveiraMaria Tereza da Costa OliveiraClaudia OrtizAmany GhoniemKamal FahmyHossam A AshmonyDovile VidebaekDanni DanielsRoberta PastoreSimarjit SinghEmmanuel TondoJayantha B L LiyanageMohammed SharifuzzamanVarja GrabovacNyambat BatmunkhJosephine LogronioGeorge ArmahFrancis E DennisMapaseka SeheriNonkululeko MagagulaJeffrey MphahleleJose Paulo G LeiteIrene T AraujoTulio M FumianHanan El MohammadyGalina SemeikoElena SamoilovichSidhartha GiriGagandeep KangSarah ThomasJulie BinesCarl D KirkwoodNa LiuDeog-Yong LeeMirren Iturriza-GomaraNicola Anne PageMathew D EsonaM Leanne WardCourtnee N WrightSlavica Mijatovic-RustempasicJacqueline E TateUmesh D ParasharJon GentschMichael D BowenFatima SerhanRotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease burden but may also be changing the rotavirus genetic landscape and driving the emergence of new genotypes. We report genotype data of more than 16,000 rotavirus isolates from 40 countries participating in the Global Rotavirus Surveillance Network. Data from a convenience sample of children under five years of age hospitalized with acute watery diarrhea who tested positive for rotavirus were included. Country results were weighted by their estimated rotavirus disease burden to estimate regional genotype distributions. Globally, the most frequent genotypes identified after weighting were G1P[8] (31%), G1P[6] (8%) and G3P[8] (8%). Genotypes varied across WHO Regions and between countries that had and had not introduced rotavirus vaccine. G1P[8] was less frequent among African (36 vs 20%) and European (33 vs 8%) countries that had introduced rotavirus vaccines as compared to countries that had not introduced. Our results describe differences in the distribution of the most common rotavirus genotypes in children with diarrhea in low- and middle-income countries. G1P[8] was less frequent in countries that had introduced the rotavirus vaccine while different strains are emerging or re-emerging in different regions.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001358&type=printable |
| spellingShingle | Sebastien Antoni Tomoka Nakamura Adam L Cohen Jason M Mwenda Goitom Weldegebriel Joseph N M Biey Keith Shaba Gloria Rey-Benito Lucia Helena de Oliveira Maria Tereza da Costa Oliveira Claudia Ortiz Amany Ghoniem Kamal Fahmy Hossam A Ashmony Dovile Videbaek Danni Daniels Roberta Pastore Simarjit Singh Emmanuel Tondo Jayantha B L Liyanage Mohammed Sharifuzzaman Varja Grabovac Nyambat Batmunkh Josephine Logronio George Armah Francis E Dennis Mapaseka Seheri Nonkululeko Magagula Jeffrey Mphahlele Jose Paulo G Leite Irene T Araujo Tulio M Fumian Hanan El Mohammady Galina Semeiko Elena Samoilovich Sidhartha Giri Gagandeep Kang Sarah Thomas Julie Bines Carl D Kirkwood Na Liu Deog-Yong Lee Mirren Iturriza-Gomara Nicola Anne Page Mathew D Esona M Leanne Ward Courtnee N Wright Slavica Mijatovic-Rustempasic Jacqueline E Tate Umesh D Parashar Jon Gentsch Michael D Bowen Fatima Serhan Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. PLOS Global Public Health |
| title | Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. |
| title_full | Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. |
| title_fullStr | Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. |
| title_full_unstemmed | Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. |
| title_short | Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network. |
| title_sort | rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle income countries results from the who coordinated global rotavirus surveillance network |
| url | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001358&type=printable |
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