In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n =...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0029 |
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| author | Zagorchev Plamen Ivanov Apostolova Elisaveta Georgieva Pilicheva Bissera Asenova Draganova-Filipova Milena Nenkova Kokova Vesela Yulieva Lukanov Julian Borisov |
| author_facet | Zagorchev Plamen Ivanov Apostolova Elisaveta Georgieva Pilicheva Bissera Asenova Draganova-Filipova Milena Nenkova Kokova Vesela Yulieva Lukanov Julian Borisov |
| author_sort | Zagorchev Plamen Ivanov |
| collection | DOAJ |
| description | The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity. |
| format | Article |
| id | doaj-art-d4e7b2cda3e546f998b898302c5f4cfe |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-d4e7b2cda3e546f998b898302c5f4cfe2025-02-02T19:57:25ZengSciendoActa Pharmaceutica1846-95582018-09-0168337338010.2478/acph-2018-0029acph-2018-0029In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulationsZagorchev Plamen Ivanov0Apostolova Elisaveta Georgieva1Pilicheva Bissera Asenova2Draganova-Filipova Milena Nenkova3Kokova Vesela Yulieva4Lukanov Julian Borisov5Department of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv4000Plovdiv, BulgariaDepartment of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv4000Plovdiv, BulgariaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University-Plovdiv4000Plovdiv, BulgariaDepartment of Medical Biology, Medical Faculty, Medical University-Plovdiv4000Plovdiv, BulgariaDepartment of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv4000Plovdiv, BulgariaDepartment of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv4000Plovdiv, BulgariaThe aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.https://doi.org/10.2478/acph-2018-0029peathyperalgesiawistar rats |
| spellingShingle | Zagorchev Plamen Ivanov Apostolova Elisaveta Georgieva Pilicheva Bissera Asenova Draganova-Filipova Milena Nenkova Kokova Vesela Yulieva Lukanov Julian Borisov In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations Acta Pharmaceutica peat hyperalgesia wistar rats |
| title | In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| title_full | In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| title_fullStr | In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| title_full_unstemmed | In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| title_short | In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| title_sort | in vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations |
| topic | peat hyperalgesia wistar rats |
| url | https://doi.org/10.2478/acph-2018-0029 |
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