Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway

Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway

BackgroundFruquintinib, a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown considerable efficacy in colorectal cancer (CRC) treatment. Despite its promising therapeutic effects, the precise molecular mechanisms underlying its therapeutic effects remain incompletely...

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Bibliographic Details
Main Authors: Qinqin Song, Hongjiao Wu, Ye Jin, Junzhi Hou, Jiawei Liu, Xuemei Zhang, Wanning Hu, Guogui Sun, Zhi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
fruquintinib
colorectal cancer
epithelial-mesenchymal transition (EMT)
TGF-β/Smad signaling pathway
vascular endothelial growth factor Receptor (VEGFR)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1503133/full
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