Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway

Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway

BackgroundFruquintinib, a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown considerable efficacy in colorectal cancer (CRC) treatment. Despite its promising therapeutic effects, the precise molecular mechanisms underlying its therapeutic effects remain incompletely...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qinqin Song, Hongjiao Wu, Ye Jin, Junzhi Hou, Jiawei Liu, Xuemei Zhang, Wanning Hu, Guogui Sun, Zhi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Oncology
Subjects:	fruquintinib colorectal cancer epithelial-mesenchymal transition (EMT) TGF-β/Smad signaling pathway vascular endothelial growth factor Receptor (VEGFR)
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1503133/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clinical Progress of Fruquintinib in Colorectal Cancer: An Overview
by: Yejie Xie, et al.
Published: (2025-02-01)

Liraglutide inhibits the development of colorectal cancer by regulating TGF-β/Smad3 signaling pathway and affecting epithelial-mesenchymal transition
by: Xinjian Li, et al.
Published: (2025-07-01)

Environmentally relevant concentration PFNA promotes degradation of SMAD7 to drive progression of ovarian cancer via TGF-β/SMADs signaling pathway
by: Jiamin Zhong, et al.
Published: (2024-10-01)

miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells
by: Xiaokang Tian, et al.
Published: (2019-03-01)

RUNX2 mediated epithelial mesenchymal transition induced by TGF beta and Smad signaling promotes malignant progression in glioma
by: Peng Zhou, et al.
Published: (2025-07-01)

UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway
by: Lijie Yang, et al.
Published: (2025-01-01)

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
by: Qian Huang, et al.
Published: (2022-09-01)

Tricellulin facilitates colorectal cancer metastasis through activation of the TGFβ/SMAD2/3 signalling pathway
by: Wenfang Yang, et al.
Published: (2025-04-01)

Corrigendum: Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
by: Qian Huang, et al.
Published: (2024-12-01)

PCK2 promotes invasion and epithelial-to-mesenchymal transition in triple-negative breast cancer by promoting TGF-β/SMAD3 signaling through inhibiting TRIM67-mediated SMAD3 ubiquitination
by: Tsung-Ming Chang, et al.
Published: (2025-12-01)

Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression
by: Zhengyang Guo, et al.
Published: (2025-08-01)

miR-21 and miR-155 in the regulation of TGF-β1/SMAD signaling pathway of the line breast cancer cells with different metastatic potential
by: Z. N. Nikiphorova, et al.
Published: (2015-09-01)

Raltitrexed, S-1 and fruquintinib (RSF) in the treatment of refractory metastatic colorectal cancer: study protocol for a multicenter, prospective, single-arm, phase II trial
by: Weibing Leng, et al.
Published: (2025-02-01)

HMGA2 Promotes Cellular Proliferation, Invasion and Metastasis of Laryngeal Cancer Through TGF-β/Smad Signaling Pathway
by: Xianxue WEN, et al.
Published: (2025-07-01)

Oroxylin A suppressed colorectal cancer metastasis by inhibiting the activation of the TGF-β/SMAD signal pathway
by: Ji-Ping Cao, et al.
Published: (2024-10-01)

SQLE promotes osteosarcoma progression via activating TGFβ/SMAD signaling pathway
by: Qi Song, et al.
Published: (2024-12-01)

Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via <i>circ</i>PRKCE Targeting the TGF-β/Smad7 Pathway to Inhibit Epithelial–Mesenchymal Transition
by: Zhiling Shi, et al.
Published: (2025-03-01)

The promotive role of reticulocalbin 3 (RCN3) in the pathogenesis of keloid via TGFβ1/Smad2/Smad7 signaling pathway in vitro
by: Wang HongYu, et al.
Published: (2024-12-01)

YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps
by: Xiaocong Jiang, et al.
Published: (2023-06-01)

OTUD3 inhibits breast cancer cell metastasis by regulating TGF-β pathway through deubiquitinating SMAD7
by: Chenchen Geng, et al.
Published: (2025-05-01)

SMAD4 promotes EMT in COPD airway remodeling induced by cigarette smoke through interaction with O-GlcNAc transferase
by: Ziteng Wang, et al.
Published: (2024-10-01)

Expression of individual members of the TGF-β/SMAD signalling pathway in the progression and survival of patients with colorectal carcinoma
by: Ivana Večurkovská, et al.
Published: (2024-11-01)

SIRT1 Activation Suppresses Corneal Endothelial–Mesenchymal Transition via the TGF-β/Smad2/3 Pathway
by: Yi Yu, et al.
Published: (2024-12-01)

Characterization of Epithelial–Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7
by: Hendrik Ungefroren, et al.
Published: (2024-12-01)

Role of the TGF-β/Smad3 pathway in pancreatic cancer cell growth and stem cell characteristics
by: Yanling Zhang, et al.
Published: (2025-08-01)

LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1
by: Shuaihui Wu, et al.
Published: (2025-05-01)

Combination therapy with DHA and BMSCs suppressed podocyte injury and attenuated renal fibrosis by modulating the TGF-β1/Smad pathway in MN mice
by: Yongzhang Li, et al.
Published: (2023-12-01)

Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway
by: Qiuhong Jiao, et al.
Published: (2025-05-01)

ASAP1 Promotes Epithelial to Mesenchymal Transition by Activating the TGFβ Pathway in Papillary Thyroid Cancer
by: Shiji Song, et al.
Published: (2025-08-01)

NEK2 promotes colorectal cancer progression by activating the TGF-β/Smad2 signaling pathway
by: Hai Qin, et al.
Published: (2025-01-01)

Preclinical validation of TGFβ inhibitors as a novel therapeutic strategy for post-traumatic heterotopic ossification
by: Jaira Ferreira de Vasconcellos, et al.
Published: (2025-04-01)

F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
by: Zhiqin Cao, et al.
Published: (2024-04-01)

Betulinic Acid Inhibits the Metastasis of Colon Cancer Cells through Regulating TGF-β/Smad Signaling Pathway
by: Xiaoying LIN, et al.
Published: (2020-02-01)

Exploring the molecular mechanisms and therapeutic potential of SMAD4 in colorectal cancer
by: Hui Shan, et al.
Published: (2024-12-01)

Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer
by: Mirvat Surakhy, et al.
Published: (2025-05-01)

CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism
by: Mian Liu, et al.
Published: (2025-07-01)

Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway
by: Shi-na Song, et al.
Published: (2024-10-01)

Involvement of the TGF-β pathway in epithelialmesenchymal transition promoted by the pulmonary microenvironment in Mycoplasma pneumoniae pneumonia
by: Fan Lu, et al.
Published: (2024-01-01)

Study on the mechanism of Huoxue Lishui compound in treating spontaneous hypertensive rats based on TGF-β1-Smads signaling pathway
by: YANG Shuo, et al.
Published: (2024-08-01)

NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression
by: Hexu Han, et al.
Published: (2025-01-01)